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 NEW ELECTROPHYSIOLOGICAL INSIGHTS INTO AN SCN5A MUTATION CAUSING LQT. ELECTROPHYSIOLOGICAL EVALUATION OF THE D1790G MUTATION IN SCN5A GENE CAUSING CONGENITAL LONG QT SYNDROME
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NEW ELECTROPHYSIOLOGICAL INSIGHTS INTO AN SCN5A MUTATION CAUSING LQT. ELECTROPHYSIOLOGICAL EVALUATION OF THE D1790G MUTATION IN SCN5A GENE CAUSING CONGENITAL LONG QT SYNDROME

автор Avishag L. издательство Книга по Требованию Книги
Cтраниц 108        мягкая обложка       
Аннотация:Basic researchers and cardiologists may find that this analysis helps to shed some light on the structure-function relationship of the human sodium channel, and that it can pave the way for a therapeutic rationale for the patients. KPQ mutation, is ineffective in treating D1790G patients. Furthermore, it is now well established that ion channels, including Na+ channels, can be regulated by G protein subunits. Flecainide was shown to normalize the QT-interval of D1790G patients. Over the last years different expression models showed conflicting results in trying to explain the QT prolongation in carriers of this mutation. The D1790G mutation in the C-terminus of SCN5A gene causes long-QT syndrome (LQT). These observations imply that the mechanism of QT prolongation in D1790G carriers is different. In an attempt to clarify the underlying mechanism, this work characterized the mutation electrophysiologically in frog oocytes and investigated both the involvement of G protein subunits and the effects of different medications on the mutant channel. In contrast, lidocaine, which shortens QTc in LQT3 patients who are carriers of ?
Автор: Avishag L.
Издательство: Книга по Требованию
Год:2009
Цена:
1980 руб
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Поиск: NEW ELECTROPHYSIOLOGICAL INSIGHTS INTO AN SCN5A MUTATION CAUSING LQT. ELECTROPHYSIOLOGICAL EVALUATION OF THE D1790G MUTATION IN SCN5A GENE CAUSING CONGENITAL LONG QT SYNDROME
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