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 Genetic variants in estrogen signaling pathways. Significance to cardiovascular physiology and pathophysiology
Наименование:

Genetic variants in estrogen signaling pathways. Significance to cardiovascular physiology and pathophysiology

автор Gemma F. издательство Книга по Требованию Книги
Cтраниц 232        мягкая обложка       
Аннотация:The identification of genetic variations associated with altered estrogen response is of potential public health importance. We hypothesized that genetic variants in the estrogen receptor alpha (ERalpha) gene may cause variable sensitivity to the hormone and influence an individual’s risk of cardiovascular disease, along with other estrogen-sensitive phenotypes. Insights may be gained into the pathogenesis of cardiovascular as well as other estrogen sensitive diseases contributing to the development and application of newer therapies for these disorders. It identifies novel genetic variants in these regions and examines their effect on expression of the receptor in vitro, and their association with estrogen sensitive phenotypes in different study populations. This work explores the role of ERalpha in the mediation of the atheroprotective effects of estrogen and identifies regulatory regions in the ERalpha gene important in cardiovascular tissue. Estrogen has a number of important beneficial effects in the cardiovascular system.
Автор: Gemma F.
Издательство: Книга по Требованию
Год:2009
Цена:
3190 руб
Нет в наличии
Поиск: Genetic variants in estrogen signaling pathways. Significance to cardiovascular physiology and pathophysiology
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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Этот факт подтверждает и известный американский анестезиолог L. Re del-Baker (1963) « Только недавно нам стало известно о значительно более ранних сериях успешных перфузии собак, произведенных С.С. Брюхоненко в 1929 г. К несчастью, эта работа была опубликована в русской и французской литературе, где и осталась похороненной». Остается только удивляться, что подобное произошло с изобретением, запатентованным в 1929 г. в Германии и Англии и в 1930 г во Франции. Сами же работы были опубликованы «Jour al Physiology e Pa hology Ge eral», 1929, Vol 27, № 1. И уже совершенно непонятно, когда тот же D. Melrose, в I960 г. восстановивший приоритет С.С Брюхоненко, через 26 лет в книге «Cardiopulmo ary bypass», вышедшей в 1986 г. под редакцией К aylor, и С. Lake в книге «Cardiovascular a es hesia» (1985) основоположником метода ИК называют J. Gibbo . Только в 1937 г. этот автор провел успешные эксперименты с искусственным кровообращением на кошках. С помощью сконструированного им аппарата, состоящего из насоса и оксигенатора, он пережимал легочную артерию на 25 мин, вскрывал ее и демонстрировал возможность эмболэктомии.
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