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 Lipid Based Drug Delivery Systems for Proteins. Physical stability of proteins at the oil-water interface
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Lipid Based Drug Delivery Systems for Proteins. Physical stability of proteins at the oil-water interface

автор Lene J. издательство Книга по Требованию Другие общетехнические дисциплины
Cтраниц 96        мягкая обложка       
Аннотация:A joint characteristic of many delivery systems are the presence of two phases and an interface. It is especially useful to new pharmaceutical scientists moving into this field. Since proteins are amphiphilic molecules the effect exercised by this exposure to the interface on the structure of the protein is of great importance. This book contains a literature review with emphasis on the various aspects of protein physical stability at the oil-water interface and exemplifies the major choices that have to be made when examining the structural changes in various formulations. The success of a protein depends on the development of a formulation that maintains the native protein structure and activity during preparation of the delivery system. During preparation, proteins are exposed to mechanical stress, to different excipients, to the mixing of the phase, and to the creation of an oil-water interface. Proteins are pharmaceuticals with high specificity and activity at relatively low concentrations, but to fully exploit their potential, an increased effort has been put into the research and development of suitable drug delivery concepts.
Автор: Lene J.
Издательство: Книга по Требованию
Год:2009
Цена:
1980 руб
Нет в наличии
Поиск: Lipid Based Drug Delivery Systems for Proteins. Physical stability of proteins at the oil-water interface
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
Ортомолекулярная медицина Orthomol Устрание причин заболеваний. Ортомоль это новый метод для лечения и профилактики болезней. Orthomol - ортомолекулярная медицина.
Клініко-генетичні співвідношення геморагічних інсультів та патогенетично-гемодинамічне обґрунтування...

Grow h of ac ivi y of lipid peroxida io a d pro ei oxida io is show a pa ie s wi h he u complica ed subarach oid hemorrhages a d wi h a subarach oid-ve ricular hemorrhage compara ively wi h pa ie s wi h subarach oid-i racerebral s roke a d mixed by hemorrhages. I is show , ha applica io of combi a io of prepara io s of imo op fezam o a backgrou d base herapy i complex medical rea me of subarach oid hemorrhage preve s developme of vascular co s ric io duri g all period of medical rea me , resul s i he subs a ial decli e of li ear speed of circula io of blood a d circular resis a ce i all vascular pools, is i s rume al i he bes a d quick se leme of i dexes o haemos asis, lipid peroxida io a d pro ei oxida io , a d is more effec ive ha radi io al medical rea me or medical rea me i combi a io o ly wi h imo opom. Keywords: soubarah oidal im hemorrhage, cerebral blood flow, coagula io , fibri oliz, oxidiza io of lipid peroxida io , pro ei oxida io , spasm of cerebral vessels, imo op, fezam. Перелік умовних скорочень АЧТЧ – активований частковий тромбопластиновий час САК – субарахноїдальний крововилив ПГІ – паренхіматозний геморагічний інсульт I R – міжнародне нормалізаційне відношення ОМБ – окисна модифікація білків ПІ – протромбіновий індекс ПК – протромбін по Квіку ПМА – передня мозкова артерія ПОЛ – перекисне окислення ліпідів ПЧ – протромбіновий час СМА – середня мозкова артерія ТБК – тіобарбітурова кислота ТКДГ – транскраніальна допплерографія ТЧ – тромбіновий час ФА – фібринолітична активність ФГ – фібриноген ФП – фібриляція передсердь ХА – хребтова артерія РАР – комплекс плазмін–б2-антиплазмін РІ – пульсаційний індекс RI – індекс резистентності VM – середня частота (швидкість) VS – пікова систолічна (максимальна) частота (швидкість)
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