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 Tumor Secreted grp170 as a Cancer Vaccine. Tumor secreted grp170 chaperones tumor antigens to the tumor microenvironment and induces an adaptive anti-tumor immune response
Наименование:

Tumor Secreted grp170 as a Cancer Vaccine. Tumor secreted grp170 chaperones tumor antigens to the tumor microenvironment and induces an adaptive anti-tumor immune response

автор Hilal A. издательство Книга по Требованию Органическая химия
Cтраниц 92        мягкая обложка       
Аннотация:This approach has the potential of being exploited clinically as a cancer-specific vaccine in tumors of various histological origins. Although most chaperones are intracellular proteins they can be modified into secretory proteins. This book describes an approach to target grp170 to the tumor microenvironment, which results in tumor rejection mediated by an adaptive immune response that is CD8+ dependent and accompanied by an enhanced cellular immune response against a tumor-specific antigen. Chaperones secreted into the tumor microenvironment can recruit professional APCs and promote antigen presentation and priming of T-lymphocytes. Grp170 is a major molecular chaperone/stress protein resident in the ER. It is distantly related in sequence to both hsp110 and hsp70 families. Furthermore, the secreted grp170 is shown to deliver full-length tumor antigens to the tumor microenvironment.
Автор: Hilal A.
Издательство: Книга по Требованию
Год:2009
Цена:
1980 руб
Нет в наличии
Поиск: Tumor Secreted grp170 as a Cancer Vaccine. Tumor secreted grp170 chaperones tumor antigens to the tumor microenvironment and induces an adaptive anti-tumor immune response
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
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