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Наименование: Tetrahydrobiopterin and nitric oxide synthase regulation. Generation and analysis of endothelial-targeted transgenic mouse lines over-expressing human GTP cyclohydrolase 1 автор Nicholas A. издательство Книга по Требованию Медико-биологические дисциплины Cтраниц 140        мягкая обложка        Аннотация: Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key mediator of vascular homeostasis. eNOS enzymatic activity appears to be determined by the availability of its cofactor tetrahydrobiopterin (BH4). Modest persistent increases in endothelial cell BH4 concentration by increased biosynthesis are sufficient to maintain NO bioavailability and endothelial function, even in the setting of vascular oxidative stress. BH4 bioavailability is limited by oxidative degradation in dysfunctional endothelium, and by alterations in the rate of its biosynthesis, governed by the rate-limiting enzyme GTP cyclohydrolase 1 (GTPCH). In this project novel targeted transgenic mouse lines were generated with endothelial-specific over-expression of human GTPCH. These findings suggest that strategies to augment endothelial BH4 levels, either by increased biosynthesis or by reducing BH4 oxidation, may be valuable in preventing and treating vascular disease. These studies have shown that BH4 bioavailability within the endothelium is essential for maintaining NO synthesis and reducing superoxide production by eNOS in vivo. Автор: Nicholas A. Издательство: Книга по Требованию Год: 2009 Цена: 2384 руб Нет в наличии Поиск: Tetrahydrobiopterin and nitric oxide synthase regulation. Generation and analysis of endothelial-targeted transgenic mouse lines over-expressing human GTP cyclohydrolase 1

Notiunea si clasificarea actelor juridice civile Forma ad valida em rebuie sг cupri dг о regul co юi u al ac ului juridic, efii d admisг rimi erea la o sursг ex erioarг pri care sг se de ermi e co юi u ul ac ului juridic civil. De aseme ea, ac ele juridice afla e о rapor de i erdepe de юг cu ac ele formale sau solem e, chiar dacг ele privi e separa u rebuie sг о depli eascг aceas г co diюie, rebuie o uєi sг fie ac e formale sau solem e cum ar fi, spre exemplu, ma da ul pe ru о cheierea u ui ac formal rebuie sг оmbrace forma au e icг. o as fel, ac ul juridic care de ermi г i eficaci a ea u ui ac formal sau solem rebuie sг fie єi el formal sau solem . Su ac e formale: do aюia, accep area succesiu ii sub be eficiu de i ve ar, ipo eca, co rac ul de socie a e comercialг. a)forma-co diюie de probaюiu e a ac ului juridic civil. Forma ceru г ac ului juridic pe ru a fi folosi ca mijloc de probг co s г о ceri юa о ocmirii о scris a ac ului juridic civil, fгrг ca lipsa aces ei forme sг afec eze validi a ea ac ului juridic. Forma ceru г ca o co diюie de probaюiu e a ac ului juridic, deєi u are ici o i flue юг asupra validi гюii aces uia, o uєi ea are u carac er obliga oriu, deoarece, о pri cipiu, es e i admisibil dovedirea ac ului juridic civil cu u al mijloc de probг.
Менажница (5 секций) "Садовая ягода". Менажница (5 секций). Диаметр: 24,5 см. Высота: 2,5 см. Материал: керамика. 397 руб Раздел: Менажницы Набор "Сделай слайм" (с разноцветными бусами, пенопластовые шариками, блёстки). Набор для изготовления слайма - это уникальный набор для создания оригинальной игрушки своими руками! Из компонентов набора можно сделать 575 руб Раздел: Лизуны, мялки, жвачки для рук Ковш для ванны "Flipper", с лейкой, мятный. Ковшик для купания и мытья головы Flipper в виде дельфина превратит каждое купание вашего малыша в веселую игру! Мягкий край из 406 руб Раздел: Ковшики
Biomaterial, Diagnostic Sensors, and Beyond Biomedical Applications of Nitric Oxide- Releasing/Generating Polymers. In this work, the biocompatibility of novel NO-releasing/generating materials has been evaluated via both in vitro and in vivo studies. Yiduo W. Книга по Требованию   2415 руб	PHOTODYNAMIC RELEASE OF NITRIC OXIDE FROM NITROSOTHIOLS. Glutathione and Serum Albumin The more simple linear transient absorption spectroscopy gives information on the time-scale of the photocleavage as well as that of the subsequence geminate recombination. Rojana L. Книга по Требованию   2007 руб
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ACADEMIC DELAY OF GRATIFICATION:. Motivation, Cognition, and Self-regulation of Learning Here, delay of gratification is conceptualized under the umbrella of self-regulation of learning, which represents students’ ability to control their feelings, cognition, and behavior in order to attain academic goals, select appropriate learning Hefer B. Книга по Требованию   1996 руб	REACTIVITY OF ALUMINUM OXIDE CLUSTERS. An Anion Photoelectron Spectroscopy, Mass Spectrometry, and Density Functional Theory Study of Isomeric Separation and To gain control of the catalytic reactions on its surface and to increase its utility, aluminum oxide has been the subject of many years of chemical research in both experimental and theoretical avenues. FATMA A. Книга по Требованию   1996 руб
Differenzielle Regulation des Zytokin-induzierten alternativen Spleissens des TF Gens in humanen Endothelzellen Die Regulation des alternativen Spleissens von Ferner besitzt die DNA topo I eine grosse Bedeutung fuer die Steuerung der eNOS- Isoformexpression und der damit verbundenen endothelialen NO-Synthese. Andreas E. Книга по Требованию   2361 руб	Kontrollmechanismen der Anaphase. Funktion und Regulation von Separase in Vertebraten Bisher galt folgendes Modell der eukaryontischen Anaphase: Книга по Требованию   1996 руб
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The Effect of an Applied Electric Field Diffusion Reactions at Metal–Oxide Interfaces. The author has focused on investigating the formation of a reaction phase, morphological changes, and redistribution of ions at the interface. Yeonseop Y. Книга по Требованию   2783 руб	Improving the performance of micro-machined metal oxide gas sensors. Optimization of the temperature modulation mode via pseudo-random The method, borrowed from the field of system identification, has been developed and introduced for the first time in the area of gas sensors. Alexander V.T. Книга по Требованию   3233 руб
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Regulation of Insulin Biosynthesis. in Pancreatic beta-cells by Shp2 Mice with conditional ablation of the Shp2/Ptpn11 gene in the pancreas exhibited defective glucosestimulated insulin secretion and impaired glucose tolerance. Sharon S. Z. Книга по Требованию   2415 руб	Layered Surface Acoustic Wave Based Indium Oxide Gas Sensors. Application for Ozone and Hydrogen Sensing The reader can also find a description of the fabrication of SAW devices, sensor layers’ material characterisation and the gas sensing mechanism of semiconductor metal oxide based gas sensors. Alexandru F. Книга по Требованию   2783 руб
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Lanthanum(III) oxide Lanthanum(III) oxide is La2O3, a chemical compound containing the rare earth element lanthanum and oxygen. Frederic P. M. Книга по Требованию   1394 руб	Dublin Regulation Usually, the responsible Member State will be the state through which the asylum seeker first entered the EU. It is the corner stone of the Dublin System, coprised of the Dublin Regulation and the EURODAC Regulation, which establishes a Europe-wide Frederic P. M. Книга по Требованию   1190 руб
Iron Oxide Iron oxides are chemical compounds composed of iron and oxygen. Frederic P. M. Книга по Требованию   1394 руб	Iodine Oxide Atmospheric compounds containing iodine form iodine radicals which react with ozone to form iodine oxide radicals (IO) and oxygen. Frederic P. M. Книга по Требованию   1394 руб
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