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 The hippocampus, a brain component important for memory but vulnerable to stressors Studies on plasticity and neurodegeneration in rat hippocampus.
Наименование:

The hippocampus, a brain component important for memory but vulnerable to stressors Studies on plasticity and neurodegeneration in rat hippocampus.

автор Miou Z. издательство Книга по Требованию Органическая химия
Cтраниц 116        мягкая обложка       
Аннотация:In particular, the role of protein synthesis has been extensively debated. Hippocampus plays an essential role in learning and memory. Numerous studies have been directed at understanding the mechanisms underlying these processes. Hippocampus is also extremely vulnerable to numerous stressors including excitotoxicity and stroke, and the mechanisms underlying vulnerability of hippocampal neurons to stress are still not completely understood. While my studies cover both neurodegeneration and synaptic plasticity, the common pathways they share suggest that depending on activation conditions, the same pathway might act on distinct substrates and produce quite different results. Studies here are concerned with both problems. Activity-dependent activation of excitatory synapses results in cell membrane depolarization, calcium influx, brief activation of calcium-dependent signaling cascades, changes in dendritic cytoskeleton and protein synthesis; on the other hand, excessive activation of excitatory synapses elicits excessive calcium influx, prolonged activation of calcium-dependent proteases such as calpain, breakdown of calcium homeostasis and neuronal damage.
Автор: Miou Z.
Издательство: Книга по Требованию
Год:2009
Цена:
1980 руб
Нет в наличии
Поиск: The hippocampus, a brain component important for memory but vulnerable to stressors Studies on plasticity and neurodegeneration in rat hippocampus.
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