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 Gene therapy of bladder cancer and colorectal metastasis in the liver. Isulin like growth factor 2 P3 and P4 regulatory sequences controlled suicidal therapy of cancer cells
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Gene therapy of bladder cancer and colorectal metastasis in the liver. Isulin like growth factor 2 P3 and P4 regulatory sequences controlled suicidal therapy of cancer cells

автор Basim A. издательство Книга по Требованию Книги
Cтраниц 156        мягкая обложка       
Аннотация:IGF2 gene was found to be differentially overexpressed in malignant compaired to normal bladder tissue. On the basis of the findings presented in this book, a patient oriented approach to treat TCC and colon metastasis in liver is proposed. Such vectors were successfully shown in this work to selectively kill malignant tissue both in vitro and in vivo. This book describes a PhD research in which the regulatory sequences of IGF2 (P3 and P4 promoters) were used to induce killing of cancer cells in culture or cell of mouse and rat bladder TCCs and of rat colon metastasis to the liver. Therefore, by selective killing of cancer cells, which overexpress IGF2, the neighboring non- IGF2 producing tumor cells are at least partly deprived of their IGF2 supply and thus amplifying the therapeutic potential of IGF2 promoters driven vectors. Moreover, IGF2 mRNA and protein levels were previously shown to be highly upregulated in primary colorectal cancer and in colon metastasis to the liver. IGF2 plays a role in tumor development. It favors cancer cells survival, progression and metastatic ability of the tumor in an autocrine/paracrine fashion.
Автор: Basim A.
Издательство: Книга по Требованию
Год:2009
Цена:
2384 руб
Нет в наличии
Поиск: Gene therapy of bladder cancer and colorectal metastasis in the liver. Isulin like growth factor 2 P3 and P4 regulatory sequences controlled suicidal therapy of cancer cells
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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Общие принципы лечения острого алкогольного...

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