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 Influence of zinc on the normal and ischaemic retina. In vitro and in vivo studies
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Influence of zinc on the normal and ischaemic retina. In vitro and in vivo studies

автор Marta U. издательство Книга по Требованию Медико-биологические дисциплины
Cтраниц 188        мягкая обложка       
Аннотация:When very low (1 micromolar) concentrations of ZnSO4 were present during ischaemia, GABA-immunoreactivity was localised to Mueller cells, indicating that zinc prevents the metabolism of GABA in Mueller cells in the ischaemic retina. In the mammalian retina, endogenous chelatable zinc was shown to be localised mainly in the photoreceptors and retinal pigment epithelium. High (500 micromolar) concentrations of ZnSO4 potentiated reactive oxygen species formation while ameliorating lipid peroxidation. However, high (500 micromolar) levels of ZnSO4 caused lactate dehydrogenase release and alterations in GABA-immunoreactivity, and exacerbated the effects of NMDA or ischaemia to the retina. Zinc localisation in the photoreceptors varied in light and dark. Low (100 micromolar) levels of zinc sulphate (ZnSO4) counteracted glutamate- and NMDA-induced lactate dehydrogenase release in rat cortical cultures; as well as the changes in Gamma-aminobutyric acid (GABA)-immunoreactivity mediated by experimental ischaemia and NMDA in isolated rabbit retinas. When low (1 nanomol) levels of ZnSO4 were injected into the vitreous humour of the rabbit eye the retina remained unaffected.
Автор: Marta U.
Издательство: Книга по Требованию
Год:2009
Цена:
2746 руб
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Поиск: Influence of zinc on the normal and ischaemic retina. In vitro and in vivo studies
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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