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 The actin cytoskeleton and macrophages. Function and regulation of the WASp/WAVE family member, WAVE2, in macrophages
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The actin cytoskeleton and macrophages. Function and regulation of the WASp/WAVE family member, WAVE2, in macrophages

автор Wassim A. издательство Книга по Требованию Органическая химия
Cтраниц 144        мягкая обложка       
Аннотация:The mechanisms by which CSF-1 affects actin cytoskeleton and induces macrophage migration are not fully understood. The actin cytoskeleton stands central in the process of cell migration. Cell migration is a fundamental process required for normal immune system function,embryonic development,and tissue repair. We have also suggested a model for the regulation of WAVE2 activity in vivo in which IRSp53 plays a central role in mediating the interaction between Rac1 and WAVE2. Nevertheless,this process also contributes to the pathogenesis of several diseases,such as chronic inflammatory disease and tumor cell invasion. CSF-1 is an important physiological chemoattractant for macrophages. We have identified for the first time WAVE2 as a pivotal factor required for CSF-1-induced cell migration in macrophages. Dissecting the fundamental mechanisms underlying WAVE2-dependent CSF-1-induced cell migration is important for understanding macrophage-mediated diseases,like tumor metastasis, and therefore holds the promise of newly effective therapeutic approaches. In particular,very little is known regarding the role of WAVE2 protein in response to CSF-1.
Автор: Wassim A.
Издательство: Книга по Требованию
Год:2009
Цена:
2384 руб
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Поиск: The actin cytoskeleton and macrophages. Function and regulation of the WASp/WAVE family member, WAVE2, in macrophages
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
Ортомолекулярная медицина Orthomol Устрание причин заболеваний. Ортомоль это новый метод для лечения и профилактики болезней. Orthomol - ортомолекулярная медицина.
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