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 Modulation of cell survival by altering mtDNA damage and repair. Sensitizing cancer cells to oxidative stress
Наименование:

Modulation of cell survival by altering mtDNA damage and repair. Sensitizing cancer cells to oxidative stress

автор Inna S. издательство Книга по Требованию Органическая химия
Cтраниц 68        мягкая обложка       
Аннотация:The research in this book explores the ways to modulate the efficiency of mtDNA repair and evaluates its contribution to the overall cell survival. This work may be of interest to students or professionals working in the field of mtDNA repair. Mitochondrial DNA is constantly exposed to, and damaged by oxygen radicals generated by Electron Transport Chain. Introduction of Exonuclease III from E. coli into human mitochondria, either through stable transfection, or by protein transduction leads to a disruption of an efficient mtDNA repair and renders cells more sensitive to the oxidative stress. This damage can lead to a loss of genetic information about key proteins in the ETC. Modulation of mtDNA repair in this way can be a potentially useful treatment strategy for pathological conditions were a destruction of abnormal cells is a desired outcome, as in anticancer therapy. What may follow is a dysfunction in cellular energy production and cell death, unless it is repaired. An efficient DNA repair mechanism in mitochondria keeps the amount of damage at an acceptably low level.
Автор: Inna S.
Издательство: Книга по Требованию
Год:2009
Цена:
1996 руб
Нет в наличии
Поиск: Modulation of cell survival by altering mtDNA damage and repair. Sensitizing cancer cells to oxidative stress
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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Газоразрядные мониторы

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