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 Molecular models of HIV-1 targets/drugs. Implications in resistance and rational design of novel antiviral agents
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Molecular models of HIV-1 targets/drugs. Implications in resistance and rational design of novel antiviral agents

автор Anna A. издательство Книга по Требованию Физическая химия
Cтраниц 144        мягкая обложка       
Аннотация:The combined use of anti- AIDS drugs has significantly improved the clinical management of HIV-1 infection. In last years relevant progress in the development and clinical use of drugs for treating HIV-1 infection has been made. Three HIV-1 macromolecular targets crucial for viral fitness and replication have been analyzed: the reverse transcriptase, the protease and the envelope glycoprotein gp41. Nevertheless, when antiretroviral therapy fails, new viral variants emerge, thus allowing HIV-1 to become resistant to drugs by accumulating mutations, either alone or in multiple patterns. The medicinal chemist can use these approaches to predict the effects of certain HIV-1 PR relevant mutations in presence of novel inhibitors. This book, therefore, provides new computational approaches aimed to rationalize the effects of known resistance- inducing mutations and to discover novel selective anti-HIV resistance-evading drugs. Understanding the genetic basis of resistance and cross-resistance is essential for optimizing the use of existing drugs and for designing new antiviral agents.
Автор: Anna A.
Издательство: Книга по Требованию
Год:2009
Цена:
2402 руб
Нет в наличии
Поиск: Molecular models of HIV-1 targets/drugs. Implications in resistance and rational design of novel antiviral agents
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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