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 Apoptotic and Antiapoptotic Mechanisms in the Immature Brain. Understanding the alternative roles of caspase-3 in the survival and death of neurons and astrocytes
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Apoptotic and Antiapoptotic Mechanisms in the Immature Brain. Understanding the alternative roles of caspase-3 in the survival and death of neurons and astrocytes

автор Sonia V. издательство Книга по Требованию Органическая химия
Cтраниц 172        мягкая обложка       
Аннотация:The classically defined main executioner protein of programmed cell death is caspase-3. The inhibitor of apoptosis and heat shock proteins, both responsible to protection against to death, are poorly correlated with caspase-3 in neurons, but strongly correlated in astrocytes, pointing to these proteins as relevant candidates for its blockade, which could account for the absence of astroglial cell death. It is implicated in the death of neurons, however we mainly observed it in the nucleus of activated astrocytes in the damaged cerebral hemisphere where it was marginally associated to the DNA fragmentation marker. Also, caspase-3 was found with the presence of caspase-cleaved fragments of glial fibrillary acidic protein, suggesting could be an important for astroglial cytoskeleton remodeling following injury. This suggests new non-apoptotic roles of caspase-3 in astroglial cells and mechanisms for caspase-3 blockade, improving our understanding of the mechanisms employed by astrocytes to cope with excitotoxic damage in the immature brain. The majority of these glial cells have an intense caspase-3 expression and they survive at longer periods after damage.
Автор: Sonia V.
Издательство: Книга по Требованию
Год:2009
Цена:
2768 руб
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Поиск: Apoptotic and Antiapoptotic Mechanisms in the Immature Brain. Understanding the alternative roles of caspase-3 in the survival and death of neurons and astrocytes
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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