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 Molecular Dissection of the Clonal M1T1 Group A Streptococci. Integrating Genomics, Proteomics, and Bioinformatics Tools to Define the Unique Features of a Pandemic Flesh-Eating Bacterial Strain
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Molecular Dissection of the Clonal M1T1 Group A Streptococci. Integrating Genomics, Proteomics, and Bioinformatics Tools to Define the Unique Features of a Pandemic Flesh-Eating Bacterial Strain

автор Ramy K.A. издательство Книга по Требованию Общая биология
Cтраниц 164        мягкая обложка       
Аннотация:M1T1 was among few GAS strains that have outnumbered other serotypes since the mid-1980s, and their increase in GAS populations coincided with the resurgence of invasive and severe forms of streptococcal diseases, especially the streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (NF). This book, based on my PhD dissertation, discusses unique features that may have endowed the global M1T1 clone with its unusual properties, and the genomic and evolutionary basis for its emergence and persistence. Among M1T1' s unique features are its ability to switch to a hypervirulent phenotype with a survival advantage in deep tissues; the acquisition and exchange of mosaic prophages that encode novel exotoxins; and the production of the potent DNase Sda1, which frees the bacteria from the leukocyte extracellular traps. A particular strain of the group A streptococci (GAS), known as the M1T1 clone, has exhibited unusual epidemiology and virulence, and has been largely associated with the pandemic of invasive GAS infections worldwide. The resurgence of the severe diseases was thus suspected to be a result of an unusual pathogenic potential inherent to the few reemerging strains.
Автор: Ramy K.A.
Издательство: Книга по Требованию
Год:2009
Цена:
2768 руб
Нет в наличии
Поиск: Molecular Dissection of the Clonal M1T1 Group A Streptococci. Integrating Genomics, Proteomics, and Bioinformatics Tools to Define the Unique Features of a Pandemic Flesh-Eating Bacterial Strain
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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