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 Epithelial Mechanisms in Airway Responses Induced by Hyperosmolarity. Application of a novel apparatus in understanding the mechanisms of exercise-induced asthma
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Epithelial Mechanisms in Airway Responses Induced by Hyperosmolarity. Application of a novel apparatus in understanding the mechanisms of exercise-induced asthma

автор Yi J. издательство Книга по Требованию Основы социологии
Cтраниц 168        мягкая обложка       
Аннотация:Using a novel guinea-pig trachea perfusion apparatus, we examined the effects of ion transport blockers and kinase inhibitors on the relationship of Vt and relaxation responses induced by hyperosmolar D-mannitol. Hyperventilation during exercise causes evaporative water loss and hyperosmolarity of the airway surface liquid. Inhibition of p38 potentiated the airway relaxation elicited by hyperosmolarity, thus p38 inhibitors have the treatment potential for exercise-induced asthma. JNK and PKC regulate the hyperosmolarity-induced hyperpolarization. The results indicate that the epithelial bioelectric and muscle relaxation responses are not regulated by a common kinase signaling pathway. Mucosal hyperosmolar challenge elicits airway transepithelial potential (Vt) changes followed by muscle relaxation mediated by epithelium- derived relaxing factor (EpDRF). We hypothesize that hyperosmolar challenge activates stress-sensitive protein kinases (PK)s in epithelium, and that the activity of PK(s) regulates epithelial bioelectric events and EpDRF release. In many cell types ion transport and functional responses are regulated by kinase signaling.
Автор: Yi J.
Издательство: Книга по Требованию
Год:2009
Цена:
2768 руб
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Поиск: Epithelial Mechanisms in Airway Responses Induced by Hyperosmolarity. Application of a novel apparatus in understanding the mechanisms of exercise-induced asthma
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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Russia and the international economy

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