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 Coagulation protein FVIII binding to phospholipid membranes. investigated by Fluorescence Correlation Spectroscopy
Наименование:

Coagulation protein FVIII binding to phospholipid membranes. investigated by Fluorescence Correlation Spectroscopy

автор Hanna E. издательство Книга по Требованию Другие общетехнические дисциплины
Cтраниц 112        мягкая обложка       
Аннотация:Here, the mechanism of coagulation factor VIII binding to membranes, a key element in the intravascular pathway of the coagulation cascade, is investigated using Fluorescence Correlation Spectroscopy. Fluorescence Correlation Spectroscopy allows one to measure these dynamics and interactions quantitatively in buffer as well as in their biological environment. Comparison of experiments on factor VIII binding in buffer and in plasma elucidates such influences. The natural environment can strongly influence biological processes, such as coagulation. Furthermore, the dynamics of the actin-cytoskeleton of living cells is studied and a drug delivery system based on lipid-coated nanoparticles is described and characterized. The interplay of factor VIII binding with competing proteins is studied on the example of annexin V. The latter has a very efficient regulatory influence on factor VIII binding, which is modeled quantitatively. Dynamics and interactions of proteins and membranes are essential biological processes.
Автор: Hanna E.
Издательство: Книга по Требованию
Год:2010
Цена:
2361 руб
Нет в наличии
Поиск: Coagulation protein FVIII binding to phospholipid membranes. investigated by Fluorescence Correlation Spectroscopy
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