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 O-linked N-Acetylglucosaminylation of Sp1 Inhibits the HIV-1 Promoter. Sweet Perspectives to Repress the Human Immunodeficiency Virus Type-1
Наименование:

O-linked N-Acetylglucosaminylation of Sp1 Inhibits the HIV-1 Promoter. Sweet Perspectives to Repress the Human Immunodeficiency Virus Type-1

автор Ramona J. издательство Книга по Требованию Органическая химия
Cтраниц 120        мягкая обложка       
Аннотация:OGT blocks the cellular transcription factor Sp1, which is essential for the replication of HIV-1 and thereby represses virus propagation. HIV-1 gene expression and replication is regulated by the binding of cellular transcription factors to specific regulatory sites in the 5' -long terminal repeat (LTR) promoter. In this study it is demonstrated that the cell' s glucose metabolism represses the replication of HIV- 1. This is based on the enzyme O-GlcNAc transferase (OGT), which is activated by increased glucose concentration and modifies proteins posttranslationally with the monosaccharide O- GlcNAc. To date, there is neither a vaccine against HIV-1, nor a cure for AIDS available. Hence, the establishment of a metabolic treatment might supplement the repertoire of antiretroviral therapies against AIDS. The AIDS pandemic is caused by the Human Immunodeficiency Virus Type-1 (HIV-1).
Автор: Ramona J.
Издательство: Книга по Требованию
Год:2009
Цена:
2361 руб
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Поиск: O-linked N-Acetylglucosaminylation of Sp1 Inhibits the HIV-1 Promoter. Sweet Perspectives to Repress the Human Immunodeficiency Virus Type-1
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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