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 Nuclear-cytoplasmic translocation of the transporter regulator RS1. Mechanism and control
Наименование:

Nuclear-cytoplasmic translocation of the transporter regulator RS1. Mechanism and control

автор Alina F. издательство Книга по Требованию Другие общетехнические дисциплины
Cтраниц 112        мягкая обложка       
Аннотация:A nuclear shuttling signal (NS) in pRS1 was identified that mediates translocation of RS1 into and out of the nucleus via importin ss1 and CRM1, respectively. According to the proposed model, in subconfluent cells, RS1 is actively imported into the nucleus whereas nuclear export of RS1 is not active. After confluence, phosphorylation of serine 370 of pRS1 by PKC takes place leading to enhancement of RS1 nuclear export and predominantly cytoplasmic distribution of the protein. In the present study, the mechanism and regulation of confluence-dependent nuclear location of RS1 was investigated. Nuclear location of RS1 was found to be regulated by the cell cycle. The RS1 protein participates in regulation of Na+-D-glucose cotransporter SGLT1 and other solute carriers. Gene expression profiling of mouse embryonic fibroblasts with RS1-/- genotype suggests that transcriptional regulation by RS1 might be important for the cell cycle and cell division. The adjacent protein kinase C (PKC) phosphorylation site was shown to control nuclear localization driven by NS during confluence. Thus, RS1 might play a role in the regulation of the solute carriers during specific phases of the cell cycle.
Автор: Alina F.
Издательство: Книга по Требованию
Год:2009
Цена:
2361 руб
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Поиск: Nuclear-cytoplasmic translocation of the transporter regulator RS1. Mechanism and control
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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Notiunea si clasificarea actelor juridice civile

Forma ad valida em rebuie sг cupri dг о regul co юi u al ac ului juridic, efii d admisг rimi erea la o sursг ex erioarг pri care sг se de ermi e co юi u ul ac ului juridic civil. De aseme ea, ac ele juridice afla e о rapor de i erdepe de юг cu ac ele formale sau solem e, chiar dacг ele privi e separa u rebuie sг о depli eascг aceas г co diюie, rebuie o uєi sг fie ac e formale sau solem e cum ar fi, spre exemplu, ma da ul pe ru о cheierea u ui ac formal rebuie sг оmbrace forma au e icг. o as fel, ac ul juridic care de ermi г i eficaci a ea u ui ac formal sau solem rebuie sг fie єi el formal sau solem . Su ac e formale: do aюia, accep area succesiu ii sub be eficiu de i ve ar, ipo eca, co rac ul de socie a e comercialг. a)forma-co diюie de probaюiu e a ac ului juridic civil. Forma ceru г ac ului juridic pe ru a fi folosi ca mijloc de probг co s г о ceri юa о ocmirii о scris a ac ului juridic civil, fгrг ca lipsa aces ei forme sг afec eze validi a ea ac ului juridic. Forma ceru г ca o co diюie de probaюiu e a ac ului juridic, deєi u are ici o i flue юг asupra validi гюii aces uia, o uєi ea are u carac er obliga oriu, deoarece, о pri cipiu, es e i admisibil dovedirea ac ului juridic civil cu u al mijloc de probг.
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