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 About nonsense-mediated quality control mechanisms in mammals. Graduate School for Cellular and Biomedical Sciences
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About nonsense-mediated quality control mechanisms in mammals. Graduate School for Cellular and Biomedical Sciences

автор Lukas S. издательство Книга по Требованию Другие общетехнические дисциплины
Cтраниц 104        мягкая обложка       
Аннотация:Nonsense-mediated mRNA decay (NMD) recognizes and degrades mRNAs that harbor a premature translation termination codon (PTC). Furthermore, PTC- containing mRNAs can be stabilized by bringing the poly(A) tail in close spatial proximity of the PTC, and consistently, PTC-containing mRNAs are stabilized by tethering of poly(A)-binding protein. In order to assure the high accuracy of gene expression, eukaryotes have evolved diverse quality- control mechanisms that recognize and degrade messenger RNAs (mRNAs) that fail to encode a complete and functional protein. Most importantly, these results demonstrate that spatial rearrangements of the 3' UTR can modulate the NMD pathway and thereby provide a novel mechanism for posttranscriptional gene regulation. We found that normal mRNAs can be turned into an NMD substrate by elongating the 3' untranslated region (3' UTR) in mammalian cells. Together with studies performed in other eukaryotes, we propose an evolutionary conserved, unified model for PTC recognition. A central step is the distinction of a PTC from a normal translation termination codon. Yet, the molecular mechanism of NMD is not solved.
Автор: Lukas S.
Издательство: Книга по Требованию
Год:2009
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2361 руб
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Поиск: About nonsense-mediated quality control mechanisms in mammals. Graduate School for Cellular and Biomedical Sciences



Higher Education in The U.K.

МИНИСТЕРСТВО ОБРАЗОВАНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ ВОЛГОГРАДСКИЙ ГОСУДАРСТВЕННЫЙ ТЕХНИЧЕСКИЙ УНИВЕРСИТЕТ КАФЕДРА ИНОСТРАННЫХ ЯЗЫКОВ Семестровая работа за 1 семестр На тему: Higher educa io i he USA Выполнил: студент группы ИВТ-161, Вавилин А.Ю. Проверил: Краткая рецензия: . . . . Оценка работы баллов. Волгоград 2003Higher Educa io i he USA. Fi ishi g school is he begi i g of a i depe de life for millio s of school gradua es. Ma y roads are ope before hem. Bu i is o a easy hi g o choose a professio ou of more ha he 2000 exis i g i he world. Ou of he more ha hree millio s ude s who gradua e from high school each year, abou o e millio go o for Q Quali y of research facili ies - Качество средств обслуживания исследования W Whe her - Ли Widespread - Широко распространенный Wi hi - В пределах
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