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 Parameters of intrathymic regulatory T cell differentiation. Thymic Treg development does not require a dedicated antigen-presenting cell type but is under T cell-intrinsic control
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Parameters of intrathymic regulatory T cell differentiation. Thymic Treg development does not require a dedicated antigen-presenting cell type but is under T cell-intrinsic control

автор Gerald W. издательство Книга по Требованию Органическая химия
Cтраниц 80        мягкая обложка       
Аннотация:The majority of regulatory T cells (Tregs) are believed to be of thymic origin. It has been hypothesized that this may result from unique intrathymic environmental cues, possibly requiring a dedicated antigen presenting cell (APC). We propose that the intrinsically high predisposition of immature thymocytes to Treg development may contribute to the predominantly thymic origin of the Treg repertoire. The underlying instructive stimulus, however, does not require unique features of a dedicated APC and can be delivered by hematopoietic as well as epithelial thymic stromal cells. We found that upon exposure of monoclonal T cells of sequential developmental stages to a thymic microenvironment expressing cognate antigen, the efficiency of Treg induction inversely correlated with progressive maturation. However, T cell intrinsic developmental regulation of the susceptibility to Treg differentiation remains a mutually non-exclusive scenario. In support of quantitative but not qualitative features of external cues being critical, thymic epithelial cells as well as different thymic dendritic cell (DC)-subtypes efficiently induced Treg development of immature thymocytes.
Автор: Gerald W.
Издательство: Книга по Требованию
Год:2009
Цена:
2361 руб
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Поиск: Parameters of intrathymic regulatory T cell differentiation. Thymic Treg development does not require a dedicated antigen-presenting cell type but is under T cell-intrinsic control
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
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Evaluating the GPRS Radio Interface for Different Quality of Service...

I co ras o he models developed i , our approach addi io ally represe s he mobili y of users hrough arrival ra es of ew GSM a d GPRS users as well as ha dover ra es of GSM a d GPRS users from eighbori g cells. Fur hermore, we co sider users wi h differe QoS profiles modeled by a weigh ed fair queuei g scheme accordi g o . he remai der of he paper is orga ized as follows. Sec io 2 describes he basic GPRS e work archi ec ure, he radio i erface, a d differe QoS profiles, which will be co sidered i he simula or. I Sec io 3 we describe he sof ware archi ec ure of he GPRS simula or, de ails abou he mobili y of GSM a d GPRS users, he way we modeled quali y of service profiles, a d he workload model we used. Resul s of he simula io s udies are prese ed i Sec io 4. We provide curves for average carried raffic a d packe loss probabili ies for differe cha el alloca io schemes a d packe priori ies as well as curves for average hroughpu per GPRS user.3 he Simula io Model We co sider a clus er comprisi g of sever hexadiago al cells i a i egra ed GSM/GPRS e work, servi g circui -swi ched voice a d packe -swi ched da a calls. he performa ce s udies prese ed i Sec io 4 were co duc ed for he i ermos cell of he seve cell clus er.
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