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 Bootstrap methods for multi-factorial dose-response designs. Methodology and applications
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Bootstrap methods for multi-factorial dose-response designs. Methodology and applications

автор Peter F. издательство Книга по Требованию Математический анализ. Кратные и криволинейные интегралы. Задачи, решения
Cтраниц 104        мягкая обложка       
Аннотация:The power of the existing methods strongly depends on a nuisance parameter representing how much the respective means differ between the groups treated by the component drugs. Researchers are interested in the question if a combination has a significantly higher efficacy than either component drug alone. The methods described are also expanded to related problems and more general questions and their power is evaluated by simulation studies. Bifactorial designs are used to test for the efficacy of fixed combinations of two (or more) drugs. In this work, the distributions of the respective test statistics are approximated by bootstrap methods with data-based estimation of the marginal differences to overcome these limitations. Finally, some examples for typical applications are worked out. Furthermore, the methods are only applicable under rather strict assumptions on the data. This gives interesting insights about the role of unknown nuisance parameters in resampling procedures.
Автор: Peter F.
Издательство: Книга по Требованию
Год:2009
Цена:
2361 руб
Нет в наличии
Поиск: Bootstrap methods for multi-factorial dose-response designs. Methodology and applications
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
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