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 Innate immune signalling. NF-kappaB activation in infections with Helicobacter pylori or Legionella pneumophila
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Innate immune signalling. NF-kappaB activation in infections with Helicobacter pylori or Legionella pneumophila

автор Sina B. издательство Книга по Требованию Общая биология
Cтраниц 112        мягкая обложка       
Аннотация:This dual role provides a mechanistic link between infections and cancer development, as seen during infection with the carcinogenic bacterium Helicobacter pylori. But how is NF-kappaB activated in these infections? And how is the activation terminated? The author introduces us to NF-kappaB signalling and then analyses NF-kappaB activation during infections with H. pylori or L. pneumophila. She establishes a new test system for high-throughput screenings and identifies new cellular factors important in NF-kappaB activation and termination. Upon infection the protein NF-kappaB acts as a central signal transmitter of the innate immune system. The identification of these factors broadens our understanding of innate immune signalling. During infection the human body interacts intimately with the infectious pathogen. It is this interaction that determines disease outcome. Bacteria that develop intracellularly, such as Legionella pneumophila, depend on the survival of the host cell and can thus benefit from NF-kappaB activation. This protein has two main functions: the activation of genes important for inflammation as well as those that secure survival of the cell.
Автор: Sina B.
Издательство: Книга по Требованию
Год:2009
Цена:
2361 руб
Нет в наличии
Поиск: Innate immune signalling. NF-kappaB activation in infections with Helicobacter pylori or Legionella pneumophila
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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