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 Impact of single strand annealing on DNA repair in mammalian cells. A component of the double strand break repair network
Наименование:

Impact of single strand annealing on DNA repair in mammalian cells. A component of the double strand break repair network

автор Wael Y.M. издательство Книга по Требованию Другие общетехнические дисциплины
Cтраниц 108        мягкая обложка       
Аннотация:Whereas GC mostly ensures accurate repair, neither NHEJ nor SSA does. According to this hierarchy, high-fidelity NHEJ dominates and suppresses the other two repair pathways. If one of central repair proteins is missing or the damage signalling is disturbed, these repair pathways crosstalk with each other in order to maintain the survival even at the expense of repair fidelity. In order to avoid the deleterious effect of double strand breaks (DSBs), mammalian cells have evolved three efficient repair pathways namely; nonhomologous endjoining (NHEJ), gene conversion(GC)and single strand annealing (SSA). In the current work we propose a model for a functional hierarchy for DSB repair network in mammalian cells. These pathways differ not only in the underlying mechsnism but also in the fidelity of the repair. The misrepair of DSBs may induce genetic alterations with consequences such as cell death or cancer. As the DNA damage signalling is impaired in most tumours, assessing the crosstalk and the hierarchy between repair pathways in tumour cells would be of most important in the future. GC also dominates over and suppresses the most deleterious SSA repair pathway.
Автор: Wael Y.M.
Издательство: Книга по Требованию
Год:2009
Цена:
2361 руб
Нет в наличии
Поиск: Impact of single strand annealing on DNA repair in mammalian cells. A component of the double strand break repair network



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