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 Molecular mechanisms of the effect of the mood stabilizer lithium. On the mechanism of the effect of lithium on cAMP-induced CREB transcriptional activity
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Molecular mechanisms of the effect of the mood stabilizer lithium. On the mechanism of the effect of lithium on cAMP-induced CREB transcriptional activity

автор Annette H. издательство Книга по Требованию Другие общетехнические дисциплины
Cтраниц 208        мягкая обложка       
Аннотация:Thus the study suggests a novel mechanism of lithium action that may contribute to the therapeutic effect of lithium in the treatment of bipolar disorder. Recently, the CREB-coactivator TORC (transducer of regulated CREB) has been identified as a novel target of lithium. CREB (cAMP response element binding protein) is a transcription factor known to mediate neuronal adaptation. Chronic treatment with lithium is required to establish mood stabilization, suggesting the involvement of processes of neural plasticity. In the present study, several different methods were used to examine the molecular mechanism by which lithium stimulates cAMP-induced CRE/CREB-mediated gene transcription through TORC. The acquired data support the notion that lithium directly facilitates the interaction between CREB and TORC, thereby enhancing CREB-directed transcription. Lithium salts are used to treat bipolar disorder, but the mechanisms accounting for the clinical efficacy are not completely understood.
Автор: Annette H.
Издательство: Книга по Требованию
Год:2009
Цена:
3986 руб
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Поиск: Molecular mechanisms of the effect of the mood stabilizer lithium. On the mechanism of the effect of lithium on cAMP-induced CREB transcriptional activity
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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