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 sh-RNA vermittelte Herabregulation der PKC? in Engineered Heart Tissue. Molekulare und funktionelle Auswirkungen einer adenoviralen Uberexpression von sh-PKC? in Rattenkardiomyozyten und rekonstituiertem Herzmuskelgewebe
Наименование:

sh-RNA vermittelte Herabregulation der PKC? in Engineered Heart Tissue. Molekulare und funktionelle Auswirkungen einer adenoviralen Uberexpression von sh-PKC? in Rattenkardiomyozyten und rekonstituiertem Herzmuskelgewebe

автор Jasmin S. издательство Книга по Требованию Математический анализ. Кратные и криволинейные интегралы. Задачи, решения
Cтраниц 120        мягкая обложка       
Аннотация:Dabei bestand eine signifikante negative Korrelation zwischen Kontraktilitaet und PKC? -mRNA-Gehalt. Diese Beobachtungen unterstreichen den kausalen Zusammenhang zwischen dem PKC? -Gehalt und der Kontraktionskraft der jeweiligen Kardiomyozyten. Diese Herabregulation der PKC? fuehrte in EHTs zu einer um 60% gesteigerten Kontraktionskraft. Hierfuer wurden Adenoviren generiert, die die Sequenz fuer eine sh-RNA gegen PKC? gerichtet codieren. Eine Transduktion in Kardiomyozyten ging mit einer 80%igen Herabregulation der PKC? auf mRNA-Ebene und einem 50%igen knockdown auf Proteinebene einher. Die Herzinsuffizienz und ihre Komplikationen stellen eine der haeufigsten Todesursachen dar. Ziel der vorliegenden Arbeit war es, die Eignung eines RNAi-vermittelten spezifischen PKC? knockdown als potentiellen therapeutischen Ansatz auf zellulaerer Ebene in Kardiomyozyten und rekonstituiertem Herzmuskelgewebe (EHT) zu untersuchen. Die Suche nach neuen medikamentoesen Angriffspunkten ist heute ein Hauptgegenstand der Herz-Kreislaufforschung. Ein moegliches Arzneimittel-Target ist die Proteinkinase C alpha (PKC? ), die kuerzlich als ein negativer Regulator der Kontraktionskraft identifiziert worden ist.
Автор: Jasmin S.
Издательство: Книга по Требованию
Год:2010
Цена:
2361 руб
Нет в наличии
Поиск: sh-RNA vermittelte Herabregulation der PKC? in Engineered Heart Tissue. Molekulare und funktionelle Auswirkungen einer adenoviralen Uberexpression von sh-PKC? in Rattenkardiomyozyten und rekonstituiertem Herzmuskelgewebe



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