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 Transcription Induction Integrated by Nuclear Receptor Coregulators. Chromatin, SF-1, and CtBP Structural and Post- Translational Modifications Induced by ACTH/cAMP Accelerate CYP17 Transcription Rate
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Transcription Induction Integrated by Nuclear Receptor Coregulators. Chromatin, SF-1, and CtBP Structural and Post- Translational Modifications Induced by ACTH/cAMP Accelerate CYP17 Transcription Rate

автор Eric D. издательство Книга по Требованию Книги
Cтраниц 168        мягкая обложка       
Аннотация:Chromatin IP (ChIP) and mammalian two hybrid experiments identified complexes which are cAMP-inducible, but sensitive to the SF-1 antagonist sphingosine. In addition, ACTH/cAMP signaling in adrenal cortex alters SF-1-containing chromatin- modifying complexes during the early phase of transcriptional induction of CYP17. Studies carried out during the past decade have shown that transcription of inducible eukaryotic genes involves sequential chromatin modifications by promoter-specific transcription factors and a class of proteins called transcription coregulators. First, this work identifed important chromatin modifications and modifying complexes at the CYP17 transcription start site and nearby steroidogenic factor-1 (SF-1) binding site. Thus, signaling, metabolism, and transcription are integrated. Last, certain corepressors are protein kinase A (PKA) targets and are functionally sensitive to PKA- dependent NADH accumulation. Post translational modifications (PTMs) to SF-1 also occur as this transcription factor interacts with the promoter. SF-1 PTMs at the ligand binding pocket opening were found to be required for CYP17 transcription.
Автор: Eric D.
Издательство: Книга по Требованию
Год:2009
Цена:
2768 руб
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Поиск: Transcription Induction Integrated by Nuclear Receptor Coregulators. Chromatin, SF-1, and CtBP Structural and Post- Translational Modifications Induced by ACTH/cAMP Accelerate CYP17 Transcription Rate
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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