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 A Computational Investigation of Selective DNA Methylation. Site and Sequence Specificity
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A Computational Investigation of Selective DNA Methylation. Site and Sequence Specificity

издательство Книга по Требованию Физическая химия
Cтраниц 140        мягкая обложка       
Аннотация:This characterization of transition states was used to provide descriptions of site and sequence specific reaction patterns of methane diazonium ions at different DNA bases and at different guanine sites in sequences containing multiply stacked guanines. Methane diazonium ions, which are the reactive intermediates formed from several potent carcinogenic methylating agents including methyl nitrosourea, can simultaneously react with different DNA sites. This work provides a computational methodology that, in principle, can describe the DNA reaction specificity of a large number of mutagens and carcinogens. Ab initio quantum mechanical SCF and density functional methods have been employed to examine diazonium ion-DNA base transition states and diazonium ion-oligonucleotide model transition states in the gas phase and in an aqueous environment. This has been directly linked to mutagenic and carcinogenic activity. Many alkylating agents covalently bind to nucleophilic positions in cellular DNA, causing DNA damage.
Издательство: Книга по Требованию
Год:2008
Цена:
2402 руб
Нет в наличии
Поиск: A Computational Investigation of Selective DNA Methylation. Site and Sequence Specificity
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
Ортомолекулярная медицина Orthomol Устрание причин заболеваний. Ортомоль это новый метод для лечения и профилактики болезней. Orthomol - ортомолекулярная медицина.
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О li era ura de speciali a e di юara oas rг, pu c ul de vedere asupra poziюiei logicii о sis emul є ii юelor logicii juridice, о sis emul є ii юelor logicii au diferi . As fel, profesorul Gheorghe E escu co siderг cг exis г o logicг judiciarг о cadrul logicilor orma ive, iar profesorul Pe ru Bo eza recu oaє e apor ul drep ului la co s ruirea eoriei argume гrii. О ge eral se are о vedere u ilizarea regulilor о ac ivi a ea prac icг de realizare a drep ului (logica juridicг) єi mai puюi ca u dome iu dis i c de aplicare a logicii о procesul specific de cu oaє ere juridicг, ca o dialec icг a gв dirii juridice, a logicii ac ului de creaюie о drep .         I difere de poziюiile exprima e co siderгm cг pri cipiile logicii formale u se ra spu mu ais mu a dis о dome iul juridic. Ele capг г o expresie specificг о drep . Exprimв d o aseme ea cali a e, Kalimowski, defi eє e as fel logica juridicг: “ S udiul gв dirii juridice discursive о oa г о i derea aces uia adicг о oa e operaюiile ei i elec uale pe care le efec ueazг о elaborarea, i erpre area єi aplicarea drep ului (G.
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