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 Localization of BMP Receptors in Specific Plasma Membrane Microdomains. Caveolae, Lipid Rafts and Clathrin-coated Pits - Impact of Endocytic Pathways on BMP Signaling
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Localization of BMP Receptors in Specific Plasma Membrane Microdomains. Caveolae, Lipid Rafts and Clathrin-coated Pits - Impact of Endocytic Pathways on BMP Signaling

издательство Книга по Требованию Другие общетехнические дисциплины
Cтраниц 156        мягкая обложка       
Аннотация:BMP signaling is initiated at two types of transmembrane serine/threonine kinases, BRI and BRII. Binding of BMP2 to PFCs results in activation of the Smad pathway, whereas BISCs initiate the activation of Smad-independent pathways via p38 resulting in the induction of Alkaline phosphatase (ALP). Its malfunctioning can cause several pathologies. These findings propose an important regulatory impact of different endocytic routes and membrane regions on BMP signaling as well as that a distinct membrane localization of BMP receptors account for specific signaling properties initiated at PFCs or BISCs. BMPs are members of the TGF-? superfamily and are involved in the regulation of proliferation, differentiation, chemotaxis and apoptosis. BMP receptor activation occurs upon ligand binding to preformed complexes (PFCs) or BMP2-induced signaling complexes (BISCs) composed of BRI and BRII. In this book, the localization of BMP receptors in distinct membrane domains and the consequential impact on BMP signaling are described. Endocytosis of growth factor receptors plays an important role in the activation, propagation and attenuation of signaling pathways.
Издательство: Книга по Требованию
Год:2008
Цена:
2402 руб
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Поиск: Localization of BMP Receptors in Specific Plasma Membrane Microdomains. Caveolae, Lipid Rafts and Clathrin-coated Pits - Impact of Endocytic Pathways on BMP Signaling
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
Ортомолекулярная медицина Orthomol Устрание причин заболеваний. Ортомоль это новый метод для лечения и профилактики болезней. Orthomol - ортомолекулярная медицина.
Висвітлення морально-етичної проблематики на шпальтах преси Православної церки Волині...

I he disser a io he co cep io s of subjec spec rum are s udied, moral-e hics problems of Voly Or hodox press are ope ed. Church publica io s, which were published i Voly a he a d of XIX – a he begi i g of XXI ce uries, a d heir cul ural-his orical backgrou d are a alysed. he problems of publica io s of Voly Or hodox Church press are i ves iga ed. he aspec s of ope i g moral-e hics problems i Voly Or hodox press are defi ed: moral-social, church- heological, church-his orical a d he problems of local lore, e hics, moral-domes ic, moral-philosophical, li erary-ar his orical problems. Ge re specific fea ures of church publica io s are revealed. he place of Voly Or hodox Church press i he sys em of religious mass-media of Ukrai e is defi ed. Key words: Or hodox press, moral-e hics problems, Voly Or hodox Church, church publicis s, religious commu ica io , co cep io s, ge re specific fea ures.
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