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 Pathway, Modulation and Modeling. New--Potentially Irreversible--Kinase Inhibitors, Computational Modeling of the Signaling Cascade, and the Effect of DiRas3 on RAF Signaling RAF Kinases:
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Pathway, Modulation and Modeling. New--Potentially Irreversible--Kinase Inhibitors, Computational Modeling of the Signaling Cascade, and the Effect of DiRas3 on RAF Signaling RAF Kinases:

автор Armin R. издательство Книга по Требованию Другие общетехнические дисциплины
Cтраниц 96        мягкая обложка       
Аннотация:Additionally the effect of the tumor suppressor DiRas3 (also known as Noey2 or ARHI) on RAF signaling was studied. A novel synthetic approach including a lyophilization step allowed us the synthesis of a diphenyl urea compound with an epoxide moiety (compound 1). Compound 1 possessed inhibitory activity in vitro. I could show that DiRas3 down-regulates the mitogenic pathway by inhibition of MEK. Furthermore, we developed a mathematical model of the Ras/RAF/MEK/ERK cascade demonstrating how stimuli induce different signal patterns and thereby different cellular responses, depending on the ratio between B-RAF and C-RAF. The development of specific irreversible kinase inhibitors is a rewarding but difficult aim. In cell culture experiments, a strong activation of the RAF signaling pathway was observed, an effect which is known from several other RAF kinase inhibitors and is here reported for the first time for a diphenyl urea compound. The Ras/RAF/MEK/ERK cascade is a central cellular signal transduction pathway involved in cell proliferation, differentiation, and survival where RAF kinases are pivotal kinases implicated in cancer.
Автор: Armin R.
Издательство: Книга по Требованию
Год:2008
Цена:
2007 руб
Нет в наличии
Поиск: Pathway, Modulation and Modeling. New--Potentially Irreversible--Kinase Inhibitors, Computational Modeling of the Signaling Cascade, and the Effect of DiRas3 on RAF Signaling RAF Kinases:
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
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