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 Search for Breast Cancer Susceptibility Genes. The Growth Hormone-1 / Insulin-like Growth Factor-1 Pathway and its Relationship to Breast Cancer
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Search for Breast Cancer Susceptibility Genes. The Growth Hormone-1 / Insulin-like Growth Factor-1 Pathway and its Relationship to Breast Cancer

автор Kerstin W. издательство Книга по Требованию Книги
Cтраниц 132        мягкая обложка       
Аннотация:During the last decades, research has revealed cancer as a complex heterogeneous disease triggered by dynamic changes in the genome. This lead to the suggestion that genetic variants in the GH1/ IGF-1 axis do not increase the mitogenic and antiproliferative features of the pathway, but rather protect the cells from proliferation. Breast Cancer is the most common cancer in Western women and represents 28% of female cancer deaths. The work in this dissertation summarizes the investigation of polymorphisms in the GH1/IGF-1 axis in relation to breast cancer risk by means of the planning and conducting of case-control studies. In summary, the studied polymorphisms were mainly associated with a decreased breast cancer risk. Many findings were novel and they reflected the complexity of the gene regulation along the GH1/IGF-1 pathway. The study contributes to the world-wide effort of identification of low-penetrance genetic variants, which may be useful tools for prevention, prognosis and planning of individual therapy.
Автор: Kerstin W.
Издательство: Книга по Требованию
Год:2008
Цена:
2415 руб
Нет в наличии
Поиск: Search for Breast Cancer Susceptibility Genes. The Growth Hormone-1 / Insulin-like Growth Factor-1 Pathway and its Relationship to Breast Cancer
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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