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 Retrograde Cellular Transport of Herpes Simplex Virus. Interactions between Viral and Motor Proteins - a Gene Therapy Vector for Spinal Cord Disease?
Наименование:

Retrograde Cellular Transport of Herpes Simplex Virus. Interactions between Viral and Motor Proteins - a Gene Therapy Vector for Spinal Cord Disease?

издательство Книга по Требованию Общая биология
Cтраниц 180        мягкая обложка       
Аннотация:To study retrograde transport of HSV-1, capsid and tegument proteins were tested for interactions with the motor cytoplasmic dynein, using a yeast two-hybrid system and in vitro pull down assays. Herpes simplex virus type 1 (HSV-1) establishes life-long latent infection in sensory neurones, making it an ideal gene therapy vector to target neuronal cells. Capsids containing VP26 moved closer to the cell nucleus, while capsids without VP26 remained in a random distribution. A strong interaction was demonstrated between the HSV-1 outer capsid protein VP26 (UL35) and the homologous 14 kDa dynein light chains RP3 and Tctex1. The functional importance of VP26 for retrograde transport was confirmed by microinjecting recombinant HSV-1 capsids into living cells. Our results suggest that the HSV-1 outer capsid protein VP26 mediates binding of incoming capsids to the retrograde motor cytoplasmic dynein during cellular infection, through interactions with dynein light chains. It is hoped that these findings will help in the development of a synthetic viral vector, which may allow targeted gene therapy in patients with neurological diseases.
Издательство: Книга по Требованию
Год:2008
Цена:
2783 руб
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Поиск: Retrograde Cellular Transport of Herpes Simplex Virus. Interactions between Viral and Motor Proteins - a Gene Therapy Vector for Spinal Cord Disease?
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
Ортомолекулярная медицина Orthomol Устрание причин заболеваний. Ортомоль это новый метод для лечения и профилактики болезней. Orthomol - ортомолекулярная медицина.
Анализ медико-социальной работы по профилактике заболеваний, передающихся половым...

Имеется также ряд заболеваний, которые могут иметь как половой, так и не половой пути передачи (папилломавирусные инфекции половых органов, генитальный контагиозный моллюск, урогенитальный шигеллёз гомосексуалистов, лобковый педикулёз, чесотка, гепатит В, амёбиаз, цитомегалия). В последние годы к перечисленным болезням присоединилось столь грозное заболевание как СПИД. Заболевания, передаваемые половым путём, представляют собой группу инфекций, которые передаются в основном при половом контакте (табл.1.1). В настоящее время в большинстве стран ИППП относятся к наиболее распространённым инфекционным болезням, подлежащим регистрации. Таблица 1.1. – Классификация ИППП Наименование заболевания Возбудитель Классические венерические болезни Сифилис Гонорея Шанкроид (мягкий шанкр) Лимфогранулематоз венерический Гранулёма венерическая (паховая) repo emma pallidum eisseria go orrhoeae Haemophilus ducreyi Chlamydia rachoma is Calymma obac erium gra uloma us Инфекции, передаваемые половым путём, с преимущественным поражением половых органов Урогенитальный хламидиоз Мочеполовой трихомониаз Урогенитальный кандидоз Мочеполовой микоплазмоз Генитальный герпес Папилломавирусные инфекции Контагиозный моллюск гениталий Бактериальный вагиноз Урогенитальный шигеллёз Лобковый педикулёз (фтириаз) Чесотка Chlamydia rachoma is richomo as vagi alis Ca dida albaca s Mycoplasma homi is Herpes simplex virus Papillomavirus homi is Molluscovirus homi is Gard erella vagi alis Shigella species Ph hirus pubis Sarcop es scabiei Инфекции, передаваемые половым путём, с преимущественным поражением других органов СПИД Гепатит В Цитомегалия Амёбиаз Лямблиоз Huma immu odeficie cy virus Hepa i is B virus Cy omegalovirus homi is E amoeba hys oly ica Lamblia (син.
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