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 Cardiac Evaluation of the Developmental Origins of Adult Cardiovascular Diseases. Insulin-like Growth Factor Binding Protein-1 and the Developmental Origins of Adult Cardiovascular Diseases
Наименование:

Cardiac Evaluation of the Developmental Origins of Adult Cardiovascular Diseases. Insulin-like Growth Factor Binding Protein-1 and the Developmental Origins of Adult Cardiovascular Diseases

издательство Книга по Требованию Медико-биологические дисциплины
Cтраниц 124        мягкая обложка       
Аннотация:This altered development likely leads to significant impairments in cardiac morphology and function in adulthood, therefore contributing to increased risk of cardiovascular diseases. This work explores the possible mechanisms that underlie this association, with focus on the insulin-like growth factor (IGF) axis. Unfortunately, the cause of this association is relatively unknown. Circulating IGFBP-1 levels are elevated in growth-restricted human fetuses, and fetal growth restriction increases the risk of cardiovascular diseases in adulthood. Their effects are modulated by the IGF binding proteins (IGFBPs). IGFs are essential regulators of fetal growth. Low birth weight has been widely shown to be correlated with drastically increased risk of developing adult cardiovascular diseases. This work reveals that transgenic mice with elevated levels of circulating IGFBP-1 in late gestation are growth restricted, and have altered cardiac morphology and function.
Издательство: Книга по Требованию
Год:2008
Цена:
2415 руб
Нет в наличии
Поиск: Cardiac Evaluation of the Developmental Origins of Adult Cardiovascular Diseases. Insulin-like Growth Factor Binding Protein-1 and the Developmental Origins of Adult Cardiovascular Diseases


ДОСТИГ ЦЕЛИ, А СЧАСТЬЕ НЕ НАСТУПИЛО?


Диференційований підхід до лікування і профілактики гострого післяпологового...

O he basis of exami a io da a here were de ec ed cli icoimmu ological charac eris ics of he cli ical course of differe acu e puerperal pyelo ephri is forms. I was proposed o apply differe ia ed herapy, which i volved he applica io of immu omodula ors, immu ocorrec ors a d de oxica oio herapy. Reaso i g from ma hema ical a alysis of he disease symp oms, here were de ec ed 14 mos probable fac ors of he disease risk. O he basis of he proposed sys em of he disease risk forecas i g here were de ec ed 92 preg a wome wi h a high risk of pyelo ephri is developme i he puerperal period. he complex of preve ive measures was applied o he pa ie s, which helped o preve he disease developme i he puerperal period. Key words: preg a wome , par urie wome , puerperal Я, disease developme risk forecas i g.
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