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 The Role of KATP Channels in Models of Midbrain Dopaminergic Neuron Loss. Open Probability Influences Neuron Survival in Vitro
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The Role of KATP Channels in Models of Midbrain Dopaminergic Neuron Loss. Open Probability Influences Neuron Survival in Vitro

издательство Книга по Требованию Органическая химия
Cтраниц 132        мягкая обложка       
Аннотация:The dopaminergic neurons of the ventral midbrain (mesDA neurons) form several distinct sub-populations which are involved in emotional control, reward behaviour and motor control. One focus of research has been to find an explanation why the SNpc neurons are more vulnerable to cellular stress than other neuronal populations. Hypothetically, the normal open-closed state of KATP channels might influence cellular survival when the mesDA neurons are under oxidative stress. In this work, I show that blocking KATP channels in vitro by pharmaceutical means has a positive effect on cell survival when mesDA are under oxidative stress. KATP channels consist of Sur1 or 2 and Kir6. 1 or 6. 2 subunits and link the metabolic state of a cell to its membrane potential. This highlights the importance of KATP channel function and may give a new direction in the development of drugs targeting Parkinson`s disease. Conversely, forced activation of KATP channels under these conditions leads to an increased rate of cell death. In patients with Parkinson`s Disease, the dopaminergic neurons of the substantia nigra, pars compacta (SNpc) gradually die.
Издательство: Книга по Требованию
Год:2008
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2415 руб
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Поиск: The Role of KATP Channels in Models of Midbrain Dopaminergic Neuron Loss. Open Probability Influences Neuron Survival in Vitro
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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