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 Metabolism and Toxicity of Trichothecenes. Studies in pigs and a risk assessment of trichothecenes in feed for farm animals
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Metabolism and Toxicity of Trichothecenes. Studies in pigs and a risk assessment of trichothecenes in feed for farm animals

автор Gunnar S.E. издательство Книга по Требованию Медико-биологические дисциплины
Cтраниц 56        мягкая обложка       
Аннотация:The micro- organisms in faeces from pigs had the ability to transform trichothecenes to de-epoxy metabolites. DON and conjugated DON were the only metabolites detected in plasma and urine. The toxins have been associated with diseases in humans and farm animals. Human faeces were not able to transform trichothecenes. No accumulation occurred in plasma. Trichothecenes are chemically closely related toxins with an epoxide ring. The ability was transferred between pigs when faeces were transferred between pens. The de-epoxides were shown to be less cytotoxic than toxins with an intact epoxide ring, verifying that the transformation is a detoxification. 3-acetyl-DON was rapidly de-acetylated and absorbed in pigs followed by a rapid excretion. No de-epoxy DON was present in plasma or urine, indicating that the de- epoxidation occurs in the lower parts of the gastrointestinal tract where the absorption is low. Feeding studies with DON and T-2 given in feed to farm animals were reviewed and guideline limits for feed proposed. Trichothecenes are mycotoxins produced by Fusarium fungi commonly found in cereals.
Автор: Gunnar S.E.
Издательство: Книга по Требованию
Год:2009
Цена:
2007 руб
Нет в наличии
Поиск: Metabolism and Toxicity of Trichothecenes. Studies in pigs and a risk assessment of trichothecenes in feed for farm animals
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