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 Regulation of the Krueppel-like Factor 6 Tumor Suppressor. Ras Promotes Cancer Cell Growth via Alternative Splicing-Mediated Inactivation of KLF6
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Regulation of the Krueppel-like Factor 6 Tumor Suppressor. Ras Promotes Cancer Cell Growth via Alternative Splicing-Mediated Inactivation of KLF6

автор Steven Y. издательство Книга по Требованию Медико-биологические дисциплины
Cтраниц 168        мягкая обложка       
Аннотация:Transcriptional targets of KLF6 include collagen 1, transforming growth factor beta 1 (TGF? 1), types I and II TGF? receptors, urokinase type plasminogen activator (uPA), and the human immunodeficiency virus long terminal repeat (HIV-1 LTR). KLF6 is a ubiquitously expressed Krueppel-like transcription factor whose role in vitro and in vivo role has not been fully identified. KLF6 directly binds DNA at GC box promoter elements. These Ras-dependent splice forms are shown to abrogate KLF6-mediated growth suppression, and ectopic KLF6 splice variant expression can restore a Ras-transformed phenotype. Here, we identify a novel mechanism of carcinogenesis, whereby oncogenic Ras signaling enhances alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinomas. Like other members of the Krueppel-like family, KLF6 contains a conserved C-terminal three zinc finger DNA-binding domain (C2H2 motifs) and a unique N-terminal transactivation domain.
Автор: Steven Y.
Издательство: Книга по Требованию
Год:2008
Цена:
2783 руб
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Поиск: Regulation of the Krueppel-like Factor 6 Tumor Suppressor. Ras Promotes Cancer Cell Growth via Alternative Splicing-Mediated Inactivation of KLF6
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
Ортомолекулярная медицина Orthomol Устрание причин заболеваний. Ортомоль это новый метод для лечения и профилактики болезней. Orthomol - ортомолекулярная медицина.
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Observarea riguroasг a aces or reguli asigurг succesul me odei, co feri du-i carac erul є ii юific i dispe sabil. 1. Prima regulг a me odei impu e a compara umai ceea ce es e comparabil. О cadrul aces ei reguli va rebui sг se co s a e, mai о вi, dacг sis emele compara e aparюi aceluiaєi ip is oric de drep sau aparюi u or sis eme is orice de drep diferi e. Dacг sis emele de drep di care fac par e i s i uюiile compara e su – ideologic vorbi d – a ago is e, es e evide cг procedeul comparaюiei u poa e fi releva decв sub aspec ul s abilirii difere юelor. Ia г, spre exemplu, dacг am dori sг comparгm regleme area i s i uюiei proprie гюii о familia drep ului roma o-germa ic (di care face par e sis emul os ru de drep ) єi familia drep ului musulma , vom u iliza a aliza de co ras (comparaюie co ras a г). I s i uюiile fii d evide deosebi e, u va fi realiza г o jux apu ere a aces ora, iar rezul a ele vor fi prea puюi acce ua e. Spre exemplu, о drep ul musulma se afla eoria eocra icг, po rivi cгreia о regul pгmв aparюi e lui Alah єi rimisul sгu Mahomed.
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