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 Computer Modeling of Enzyme Catalysis and Inhibition. A Study on ODCase Catalysis and Protein Kinase C Inhibition
Наименование:

Computer Modeling of Enzyme Catalysis and Inhibition. A Study on ODCase Catalysis and Protein Kinase C Inhibition

автор Sishi T. издательство Книга по Требованию Физическая химия
Cтраниц 92        мягкая обложка       
Аннотация:Computer modeling techniques have been extensively used to aid drug design via enzymatic reaction studies. Here we present the investigations of the catalysis by orotidine monophosphate decarboxylase (ODCase) and the inhibition of protein kinase C (PKC) isozymes. For the first time, specific interactions for ruboxistaurin that favor binding to PKC-? were uncovered. Our study provides opportunity to design isozyme-specific inhibitors for PKC. Homology modeling and docking techniques were used to model the three-dimensional structures of the kinase domains of PKC isozymes and the PKC-ruboxistaurin complexes. The catalytic site architecture and binding interactions of PKC isozymes ? , ? and ? were also investigated in the context of PKC-? inhibitor, ruboxistaurin. Decarboxylation, pseudohydrolysis and covalent inhibition reactions were studied using QM and QM/MM methods to understand the mechanistic details of ODCase catalysis.
Автор: Sishi T.
Издательство: Книга по Требованию
Год:2009
Цена:
2007 руб
Нет в наличии
Поиск: Computer Modeling of Enzyme Catalysis and Inhibition. A Study on ODCase Catalysis and Protein Kinase C Inhibition
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
Ортомолекулярная медицина Orthomol Устрание причин заболеваний. Ортомоль это новый метод для лечения и профилактики болезней. Orthomol - ортомолекулярная медицина.
Introducere

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