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 Progression toward Leukemia. Differentiation Block Occurs and Disease Progression Worsens when Activating SHP2 Mutations Synergize with Overexpressed HoxA10
Наименование:

Progression toward Leukemia. Differentiation Block Occurs and Disease Progression Worsens when Activating SHP2 Mutations Synergize with Overexpressed HoxA10

автор Stephan L. издательство Книга по Требованию Медико-биологические дисциплины
Cтраниц 164        мягкая обложка       
Аннотация:Furthermore, HoxA10 phosphorylation state, as regulated by SHP2, influences leukemia progression and provides evidence of a two-hit model of leukemogenesis in mouse experiments. This research highlights how science can be used to understand the fundamental molecular mechanisms involved in human disease to develop treatments to improve the quality of life for patients suffering from various cancers. Therefore, understanding how blood normally differentiates is critical to understanding leukemia. These differentiation-state specific phosphorylations reversed HoxA10 gene repression and allowed for further differentiation. Differentiation blocks are hallmarks of leukemia and represent the inability of these cells to develop normally. The SHP2 phosphatase maintains the dephosphorylation state of these residues in undifferentiating cells and leukemia-associated SHP2 mutations increase HoxA10 repression in both undifferentiated and differentiated cells, leading to differentiation block. HoxA10 represses lineage- specific genes in undifferentiated cells, and that during differentiation HoxA10 was phosphorylated within its homeodomain.
Автор: Stephan L.
Издательство: Книга по Требованию
Год:2009
Цена:
2783 руб
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Поиск: Progression toward Leukemia. Differentiation Block Occurs and Disease Progression Worsens when Activating SHP2 Mutations Synergize with Overexpressed HoxA10
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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