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 A Novel Target for Cancer Diagnosis and Therapy The Role of GRP78/BiP in Apoptosis Regulation and Cancer Progression.
Наименование:

A Novel Target for Cancer Diagnosis and Therapy The Role of GRP78/BiP in Apoptosis Regulation and Cancer Progression.

автор Yong F. издательство Книга по Требованию Другие общетехнические дисциплины
Cтраниц 104        мягкая обложка       
Аннотация:Searching for novel partners interacting with GRP78 at the ER, we discovered that BIK selectively forms a complex with GRP78. This effect was substantially reduced when BIK level was reduced by siRNA. GRP78, a molecular chaperone at the endoplasmic reticulum (ER), is highly elevated in malignant tumors and correlates with severe pathological grade and poor prognosis. Further, knockdown of endogenous GRP78 by siRNA sensitizes those cells to estrogen starvation. Our results provide evidences that GRP78 is critical in apoptosis regulation and cancer progression. GRP78 overexpression decreases apoptosis induced by BIK. For breast cancer cells that require BIK to mediate estrogen starvation-induced apoptosis, GRP78 overexpression inhibits estrogen starvation-induced BAX activation, mitochondrial permeability transition, and consequent apoptosis. Additionally, an in vivo study in a Pten conditional knockout mouse model of prostate cancer reveals that homozygous deletion of Grp78 blocks prostate cancer progression initiated by Pten nullification. GRP78 affects apoptosis by regulating ER Ca2+ signaling and unfolded protein response, but whether other mechanisms exist remains unknown.
Автор: Yong F.
Издательство: Книга по Требованию
Год:2009
Цена:
2007 руб
Нет в наличии
Поиск: A Novel Target for Cancer Diagnosis and Therapy The Role of GRP78/BiP in Apoptosis Regulation and Cancer Progression.
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
Ортомолекулярная медицина Orthomol Устрание причин заболеваний. Ортомоль это новый метод для лечения и профилактики болезней. Orthomol - ортомолекулярная медицина.
Патогенез

Анестезия на основе пропофола в значительно меньшей степени усиливает прооксидантные процессы и снижает антиоксидантный потенциал. Минимальное смещение окислительно-антиоксидантного гомеостаза в эксперименте, как при хирургической травме, так и без неё выявлено при анестезии пропофолом. В клинике на всех этапах хирургической травмы пропофол в меньшей степени вызывает нарастание продуктов ПОЛ, снижение антиоксидантного потенциала организма, что позволяет рассматривать его как протекторный вид анестетика. Результаты исследований стали патогенетическим обоснованием необходимости коррекции выявленных нарушений окислительно-антиоксидантного гомеостаза. Введение рекомбинантной СОД в эксперименте приводит к повышению активности СОД, как при анестезии эфиром, тиопенталом натрия, кетамином, пропофолом, так и при сочетании этих видов обезболивания с лапаротомией. Ключевые слова: хирургическая травма, обезболивание, свободнорадикальные процессы. Summary Germa K.B. Free radical processes i pa hoge esis of failures caused by surgical rauma u der differe ki ds of a aes he iza io . – A ma uscrip . Disser a io for he ca dida e of medical scie ce degree i speciali y 14.03.04 – pa hologic physiology. – Kharkiv a io al Medical U iversi y. – Kharkiv, 2008. he role of free radical processes i pa hoge esis of failures caused by surgical rauma u der differe ki ds of a aes he iza io has bee s udied. he s udy allows o es ablish ha a aes hesiological aid by differe ki ds of a aes he ics such as hiope al a rium, ke ami , propofol is followed by free radical progress which is charac erized by i e sifyi g of oxida phe ome a, i crease of co ce ra io of lipid peroxide oxida io produc s as well as reduce of a ioxida ive po e ial.
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