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 STRATEGIES FOR DELIVERY. I These functionalized gold colloids were studied for their cellular uptake. Part I: Endcaps are linkers that link the 3’ and 5’ ends of DNA duplexes.
Наименование:

STRATEGIES FOR DELIVERY. I: Synthesis and Applications of Endcapped Oligonucleotides II: Synthesis and Delivery of Amine and Guanidinium Functionalized Gold Nanoparticles

автор Pei-Sze N. издательство Книга по Требованию География
Cтраниц 176        мягкая обложка       
Аннотация:These functionalized gold colloids were studied for their cellular uptake. Part I: Endcaps are linkers that link the 3’ and 5’ ends of DNA duplexes. Endcapped CpG oligonucleotides stimulated IL-6 and IL-12 secretion and extended the life span of the tumor implanted mice beyond that of the untreated control mice. The nuclease stability of endcapped CpG oligonucleotides was established to be at least 6- fold more stable than unmodified oligonucleotides. Part II: Thiol terminated amine and guanidinium derivatives were synthesized and conjugated to 5 nm and 10 nm gold nanoparticles. The efficiency of ligation was dependent on the number of nucleotides flanking the 3’- and 5’ ends of the nick. Closed endcapped DNA duplexes were obtained by enzymatic ligation of the nicked DNA duplexes. Endcapped CpG oligonucleotides were synthesized to elucidate the mode of recognition of different forms of CpG oligonucleotides by the immune system. A series of diamide endcaps has been synthesized and shown to stabilize DNA duplexes (4 base-pair).
Автор: Pei-Sze N.
Издательство: Книга по Требованию
Год:2009
Цена:
2783 руб
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Поиск: STRATEGIES FOR DELIVERY. I: Synthesis and Applications of Endcapped Oligonucleotides II: Synthesis and Delivery of Amine and Guanidinium Functionalized Gold Nanoparticles
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
Ортомолекулярная медицина Orthomol Устрание причин заболеваний. Ортомоль это новый метод для лечения и профилактики болезней. Orthomol - ортомолекулярная медицина.
Russia and the international economy

Alo gside wi h o her provisio s his program shall embrace cus oms ariff ra es pla ed for he year i ques io as well as he ba d of heir possible fluc ua io , hus maki g he foreig rade more predic able. he Gover me has he righ o i roduce expor a d impor qua i a ive res ric io s o a io al securi y grou ds, o comply wi h i er a io al agreeme s or o pro ec he domes ic marke , however, hese measures shall be a ou ced o less ha 3 mo hs prior o heir ac ual i roduc io . he law e visages a possibili y o i roduce s a e mo opoly for rade i cer ai produc s. I his case a special procedure of lice si g impor a d expor opera io s exclusively o s a e-ow ed e erprises shall be applied.  As he above me io ed law was effec ua ed, he Commissio of he RF Gover me o Safeguard Measures i Foreig rade became fully legi ima e a d i December i received "Procedures of I ves iga io Prior o Applica io of Safeguard Measures" approved by he MFER (Russ.abbr. MVES). A possibili y o apply safeguard measures agai s compe i ive impor ed produc s complies wi h usual prac ices applicable i he world rade.
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