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 Interactions between membrane transporters and phospholipids. Phosphatidylethanolamine regulates the function and the structure of LmrP, a bacterial multidrug transporter associated to antibiotic resistance
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Interactions between membrane transporters and phospholipids. Phosphatidylethanolamine regulates the function and the structure of LmrP, a bacterial multidrug transporter associated to antibiotic resistance

автор Pierre H. издательство Книга по Требованию Экономическая теория
Cтраниц 92        мягкая обложка       
Аннотация:However, the question of how lipid molecules interact with integral membrane proteins and regulate their structure and function in biological membranes remains unsatisfactorily addressed. Highly solved crystal structures and a wealth of biochemical data are now available for an increasing number of membrane proteins. Recent experimental investigations on the proton gradient-driven multidrug transporter LmrP are also discussed. This book discusses the functional mechanisms of membrane proteins in general and the effect of the surrounding lipidic environment, in the context of recent developments in the field. Using this membrane protein as a model, we demonstrated that the protein structure and function was depending on the phosphatidylethanolamine (PE) headgroup. Because Asp-68 belongs to a highly conserved motif of the Major Facilitator Superfamily (MFS) , this interaction might be a general feature of these transporters that is involved in proton gradient sensing and lipid dependence. We then showed that a negatively charged residue, Asp68, could participate in the interaction with PE and that such interaction is required for proper activity and structure of the protein.
Автор: Pierre H.
Издательство: Книга по Требованию
Год:2009
Цена:
2007 руб
Нет в наличии
Поиск: Interactions between membrane transporters and phospholipids. Phosphatidylethanolamine regulates the function and the structure of LmrP, a bacterial multidrug transporter associated to antibiotic resistance
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
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