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 Lead Exposure. Global and Quantitative Gene Expression Analysis of the Effects of Drinking Water Exposure to Lead Acetate in Fisher 344 Male Rats Liver
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Lead Exposure. Global and Quantitative Gene Expression Analysis of the Effects of Drinking Water Exposure to Lead Acetate in Fisher 344 Male Rats Liver

автор Worlanyo G. издательство Книга по Требованию Книги
Cтраниц 276        мягкая обложка       
Аннотация:Expression profiles were clustered and gene ontology (GO) revealed 15 GO categories affected by chronic (90d) exposure, while 3 GO categories were affected during (30d) exposures. Results showed differentially expressed genes including genes cited in the literature and several not previously reported to be affected by lead toxicity. Pb controls mammalian protein synthesis via regulating phosphorylation or dephosphorylation events of eukaryotic elongation/initiation factors; Pb regulates gene expression through the regulation of histone acetylases and Pb regulates calcium dependent transcription factor myocyte enhance factor-2. Quantitative PCR was employed in validating the microarray result and showed that Microarrays and qRT-PCR yield comparable results. The primary objective of this work was to analyze global gene expression patterns occurring in Fisher 344 rat livers exposed to varying levels of lead. Pathways emphasized the importance of Pb in modulating various cellular events in a manner similar to calcium regulation, including calcium signaling phosphorylation and dephosphorylation, histone acetylation and deacetylation. Conclusions include:
Автор: Worlanyo G.
Издательство: Книга по Требованию
Год:2009
Цена:
3233 руб
Нет в наличии
Поиск: Lead Exposure. Global and Quantitative Gene Expression Analysis of the Effects of Drinking Water Exposure to Lead Acetate in Fisher 344 Male Rats Liver
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
Ортомолекулярная медицина Orthomol Устрание причин заболеваний. Ортомоль это новый метод для лечения и профилактики болезней. Orthomol - ортомолекулярная медицина.
Genetic Engineering

If rela ives of he al ered crops are growi g ear he field, he ew ge e ca easily move via polle i o hose pla s. he ew rai s migh co fer o wild or weedy rela ives of crop pla s he abili y o hrive i u wa ed places, maki g hem weeds as defi ed above. For example, a ge e cha gi g he oil composi io of a crop migh move i o earby weedy rela ives i which he ew oil composi io would e able he seeds o survive he wi er. Overwi eri g migh allow he pla o become a weed or migh i e sify weedy proper ies i already possesses.Cha ge i Herbicide Use Pa er sCrops ge e ically e gi eered o be resis a o chemical herbicides are igh ly li ked o he use of par icular chemical pes icides. Adop io of hese crops could herefore lead o cha ges i he mix of chemical herbicides used across he cou ry. o he ex e ha chemical herbicides differ i heir e viro me al oxici y, hese cha gi g pa er s could resul i grea er levels of e viro me al harm overall. I addi io , widespread use of herbicide- olera crops could lead o he rapid evolu io of resis a ce o herbicides i weeds, ei her as a resul of i creased exposure o he herbicide or as a resul of he ra sfer of he herbicide rai o weedy rela ives of crops.
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