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 BDNF signaling, translation control, and gene function LTP mechanisms in the dentate gyrus in vivo.
Наименование:

BDNF signaling, translation control, and gene function LTP mechanisms in the dentate gyrus in vivo.

автор Tambudzai K. издательство Книга по Требованию Другие общетехнические дисциплины
Cтраниц 132        мягкая обложка       
Аннотация:We have demonstrated rapid activation of both translation factors and upregulation of Arc protein during BDNF-LTP. In this study, LTP was induced in the DG by intrahippocampal infusion of brain-derived neurotrophic factor (BDNF-LTP). Alternatively, LTP was induced at medial perforant path-granule cell synapses by high frequency stimulation (HFS-LTP). The aim of the study was investigation of transcriptional and translational changes of activity-regulated cytoskeleton-associated protein (Arc/Arg3. 1) as well as changes in activation of the translation factors eIF4E (eukaryotic initiation factor 4E) and eEF2 (eukaryotic elongation factor-2) during LTP. This book illustrates some of the various molecular mechanisms underlying synaptic plasticity in a subfield of the rat hippocampus called dentate gyrus (DG). Additionally, an approach based on intrahippocampal infusion of Arc antisense oligodeoxynucleotides showed the importance of sustained Arc translation for the maintenance of both BDNF-LTP and HFS-LTP during a restricted time window. Long-term potentiation (LTP) is a well- known model for studying strengthening of synaptic plasticity.
Автор: Tambudzai K.
Издательство: Книга по Требованию
Год:2009
Цена:
2415 руб
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Поиск: BDNF signaling, translation control, and gene function LTP mechanisms in the dentate gyrus in vivo.
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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