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 A new class of antibiotics? The medicinal and chemical aspects of naphthoquinones on tuberculosis.
Наименование:

A new class of antibiotics? The medicinal and chemical aspects of naphthoquinones on tuberculosis.

автор Frank v.H. издательство Книга по Требованию Медико-биологические дисциплины
Cтраниц 132        мягкая обложка       
Аннотация:This indicates that these compounds might become a new class of antibiotics. The last chapters deal with the investigation of a structure activity relationship and propose a mechanism of action for these naphthoquinones. It furthermore deals with the chemical synthesis of the main lead compound and some derivatives. This book deals with the traditional use of plants to treat TB-like symptoms and attempts to establish a link between naphthoquinones and these plants with the use of a metabolomics approach. It was found that this class of compounds interfere with the electron transport chain by inhibiting menaquinone to bind to the cytochrome complex. These studies showed that rapid breakdown of lead compounds do occur during activity and toxicity testing, and that this leads to false positives and negatives. This is followed by the often neglected stability studies performed on the main active compounds. The activity and toxicity of the main active compounds were tested using three models: Vero cells, mice and Musca domestica. The antimycobacterial activity of several naphthoquinones initiated this study into the occurrence, chemistry and biological activity of these compounds.
Автор: Frank v.H.
Издательство: Книга по Требованию
Год:2009
Цена:
2415 руб
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Поиск: A new class of antibiotics? The medicinal and chemical aspects of naphthoquinones on tuberculosis.



Лингвистика

Сравним, например, синонимы: «class» и «form» в значении «группа учащихся»: class - group of perso ough oge her form - class i GB school, he you ges boys a d girls bei g i he firs class a d he oldes i six h Как следует из определения, «class» - это класс как группа учащихся, а «form» - предполагает их деление по возрастным ступеням Соответственно будут они отличаться: «Classroom» - room where a class is augh a d keep i s books ( he word is res ric ed o primary schools ) «Formroom» - he mea i gs as classroom bu is mai ly res ric ed o seco dary schools, where i usually de o es a room used by a par icular form for regis ra io Или сравним, например, словосочетание «классный руководитель» и «class eacher». Употребляя их в качестве эквивалентных, можно легко попасть в заблуждение, так как они обозначают реалии, имеющие существенные различия: «Классный руководитель» - учитель, который отвечает за успеваемость и поведение в классе, проводит родительские собрания, классные часы, контроллирует оценки в дневнике. «Сlass eacher» - a eacher who akes o e a d he same class for mos of i s lesso s.
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