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 Studies On the Coxsackie and Adenovirus Receptor. Functional Studies On the Coxsackie and Adenovirus Receptor
Наименование:

Studies On the Coxsackie and Adenovirus Receptor. Functional Studies On the Coxsackie and Adenovirus Receptor (CAR) in Skeletal Muscle Cells

автор Yunlin T. издательство Книга по Требованию Органическая химия
Cтраниц 88        мягкая обложка       
Аннотация:Recent studies have shown that, in integrin- expressing cells, CAR can directly mediate AV uptake without penton base RGD-av integrin interactions. Mouse brain extracts also modified the isoelectric pH of the CAR C-terminal fusion protein. Virus bound by CAR is passed to integrins which bind an RGD (Arg-Gly-Asp) sequence in the viral penton base protein and act as secondary receptors responsible for virus internalization. CAR is the primary AV receptor and integrins are secondary AV receptors. I also found that mouse brain extract reproducibly modifies the immunoreactivity of the CAR C-terminal fusion protein and increase its tendency to dimerize. To investigated the possibility that these proteins associate in a functional complex in the cell membrane, I forced CAR expression in a line of human myoblasts and obtained coprecipitation of CAR and B3 integrin suggesting these proteins may associate. I confirmed that EC+ transmembrane (TM) domains of CAR are sufficient for AV uptake in integrin-expressing cells. CAR has recently been identified as a high affinity receptor for both Coxsackievirus and certain adenovirus (AV) serotypes.
Автор: Yunlin T.
Издательство: Книга по Требованию
Год:2009
Цена:
2007 руб
Нет в наличии
Поиск: Studies On the Coxsackie and Adenovirus Receptor. Functional Studies On the Coxsackie and Adenovirus Receptor (CAR) in Skeletal Muscle Cells
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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