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 Quantitative Structure-Pharmacokinetic Relationships. Artificial Neural Network Modeling
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Quantitative Structure-Pharmacokinetic Relationships. Artificial Neural Network Modeling

C 160               
:As well as providing the theory behind ANN model construction, this book details their practical application in pharmaceutical research and gives meaning to many of the theoretically-derived molecular descriptors now available. This book describes the use of artificial neural networks (ANN) as robust nonlinear modeling tools for developing quantitative structure-pharmacokinetic relationships (QSPkR). Early pharmacokinetic optimisation is a key principle in drug discovery and development. Consideration is given to physiological processes, drug and molecular structural data, and model interpretation. A valuable resource for medicinal chemists and pharmaceutical scientists engaging in structure-property and structure-activity modeling. Modeling absorption, distribution, metabolism and excretion (ADME) using experimentally-derived data is time-consuming and expensive. Different ANN paradigms are examined for predictive modeling of various pharmacokinetic parameters, both individually and simultaneously. The use of computational in silico techniques to predict pharmacokinetic properties based on molecular structure is gaining wider validity and acceptance in the pharmaceutical industry.
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: Quantitative Structure-Pharmacokinetic Relationships. Artificial Neural Network Modeling
2013
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Introducere

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Structure-property Relationships from Digital Images. The Influence of Morphology on Physical Properties of Reservoir RockStructure-property Relationships from Digital Images. The Influence of Morphology on Physical Properties of Reservoir
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A QUANTITATIVE ANALYSIS OF SPANISH CONSONANT WEAKENING IN VENEZUELAN CHILDRENS SPEECH ACQUISITION OF PHONOLOGICAL STRUCTURE AND SOCIOLINGUISTIC VARIABLES.A QUANTITATIVE ANALYSIS OF SPANISH CONSONANT WEAKENING IN VENEZUELAN CHILDRENS SPEECH ACQUISITION OF PHONOLOGICAL STRUCTURE AND SOCIOLINGUISTIC
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The Energy Drink Market in South Africa. Competitive Structure and Consumer InsightsThe Energy Drink Market in South Africa. Competitive Structure and Consumer Insights
During the last decade Energy Drinks have been enthusiastically embraced by the sport- and party-loving South African nation. Magdalena M.  
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Multilingualism and Cosmopolitanism. Meanings, Relationships, TendenciesMultilingualism and Cosmopolitanism. Meanings, Relationships, Tendencies
It then defines individual multilingualism, establishing minimum quantitative and qualitative criteria.  
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Patterns in Beginning Readers. Cognitive and Achievement RelationshipsPatterns in Beginning Readers. Cognitive and Achievement Relationships
The results, which were analyzed by literacy ability grouping, suggest different interventions for literacy groups are indicated, making this work of interest to reading specialists, special educators, speech-language pathologists, school Deborah R.  
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To supplement the widely used methods, here we generalize the Metric Space Technique (MST), a tool used to analyze and classify astrophysical maps and perform a multi-scale analysis and get the fractal dimension of the early and current Yongfeng W.  
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Illegal Insider Trading and Corporate Ownership Structure. The Efficiency of the Acquisitions Markets and the Exploitation of Information Asymmetry in the Context of Corporate Ownership StructureIllegal Insider Trading and Corporate Ownership Structure. The Efficiency of the Acquisitions Markets and the Exploitation of Information Asymmetry in the
Without such feelings, the markets will never see tremendous highs accompanied by irrational exuberance, but neither will they see abysmal lows marked by incredible levels of pessimism and outright depression. Dr. M.I.  
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CRUSTAL STRUCTURE OF BAY OF BENGAL. INVESTIGATION OF CRUSTAL STRUCTURE IN THE BAY OF BENGAL USING MAGNETIC AND GRAVITY DATACRUSTAL STRUCTURE OF BAY OF BENGAL. INVESTIGATION OF CRUSTAL STRUCTURE IN THE BAY OF BENGAL USING MAGNETIC AND GRAVITY
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Bullying unter Schuelern. Eine empirisch-quantitative Untersuchung unter besonderer Beruecksichtigung des CyberbullyingsBullying unter Schuelern. Eine empirisch-quantitative Untersuchung unter besonderer Beruecksichtigung des Cyberbullyings
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Perturbed or not perturbed?. Structure and dynamics of fluorophore-labelled dsDNA helices probed by NMR-spectroscopyPerturbed or not perturbed?. Structure and dynamics of fluorophore-labelled dsDNA helices probed by NMR-spectroscopy
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High-Spin Gamma-Ray Spectroscopy in the A = 125 Region. Structure of Excited States in Ba and Xe IsotopesHigh-Spin Gamma-Ray Spectroscopy in the A = 125 Region. Structure of Excited States in Ba and Xe Isotopes
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The EU Directive on Services and its Economic Effects. The Evolution of Industry Structure - A Theoretical Analysis, with Special Regard to the EU Directive on ServicesThe EU Directive on Services and its Economic Effects. The Evolution of Industry Structure - A Theoretical Analysis, with Special Regard to the EU Directive on
Although the directive has received high attention in the media and in political circles, its economic implications have not been discussed thoroughly in the economic literature. Ansgar K.  
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In addition to the main topic of the book, the last chapter is dedicated to study of ultracold neutron (UCN) storage anomaly. Dmitry S.  
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Brillouin, Raman and NMR Characterization of Rare-Earth Doped Glasses. Structure, Properties and Holographic Storage ApplicationBrillouin, Raman and NMR Characterization of Rare-Earth Doped Glasses. Structure, Properties and Holographic Storage
The strength of the holographic storage signal in these photonic glass systems is analyzed from the view point of variety of important factors, such as the number of the excited europium ions, high-energy phonons associated with Si-nonbridging Zhandos U.  
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Chapters 3-6 comprise the empirical chapters: chapter 3 tests an agency model of dividends on Indian firms while chapter 4 studies the determinants of capital structure of Mauritian firms.  
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Upslope Flow Systems. Scaling, Structure, and Kinematics in Tank and AtmosphereUpslope Flow Systems. Scaling, Structure, and Kinematics in Tank and Atmosphere
This book addresses these questions using field observations and water-tank experiments.  
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Intimate Relationships: Race, Religion, Rubber, and Politics in the Liberia Education Project, 1917-1947 Church and State in the U. S. and Liberia.Intimate Relationships: Race, Religion, Rubber, and Politics in the Liberia Education Project, 1917-1947 Church and State in the U. S. and
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Managing Inter-organizational Relationships for Successful Outcomes Exploring Information Systems Outsourcing: The Role of Social Capital.Managing Inter-organizational Relationships for Successful Outcomes Exploring Information Systems Outsourcing: The Role of Social
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Daughters and their Mothers and Stepmothers. Young Women Recall their Positive Relationships with their Mothers and StepmothersDaughters and their Mothers and Stepmothers. Young Women Recall their Positive Relationships with their Mothers and
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The Killing of the Fittest. A Quantitative Analysis of HIV/AIDS and ConflictThe Killing of the Fittest. A Quantitative Analysis of HIV/AIDS and Conflict
However, what can be empirically analyzed at this point is the reverse-causal effect or the question whether conflict experience impacts on HIV-prevalence rates.  
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Prediction of Protein Structure and Function Using Spectral TechniquesPrediction of Protein Structure and Function Using Spectral Techniques
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Japanische Auslandsreisen seit 1964. Eine quantitative und qualitative BetrachtungJapanische Auslandsreisen seit 1964. Eine quantitative und qualitative Betrachtung
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A Critical Realist Analysis of Information Systems Development and Organisational Change in British Local Government Exploring the Structure- culture-agency Dynamic. Change and Reality:A Critical Realist Analysis of Information Systems Development and Organisational Change in British Local Government Exploring the Structure- culture-agency
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