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 The Role of CoREST in Gene Silencing. Initial Identification of Novel Binding Partners for the Developmentally-regulated Co-repressor
Наименование:

The Role of CoREST in Gene Silencing. Initial Identification of Novel Binding Partners for the Developmentally-regulated Co-repressor

издательство Книга по Требованию Органическая химия
Cтраниц 124        мягкая обложка       
Аннотация:The various transcription-related factors, identified in the course of the present study as novel CoREST-binding proteins strongly support this hypothesis. It is likely that CoREST is recruited to specific DNA sites by various transcription factors, of which REST is perhaps one of many. CoREST was initially identified as REST-associated protein that mediates transcriptional repression by recruitment of distinct multisubunit complexes implicated in the modification of chromatin. In contrast to REST, which is expressed primarily in non-neuronal cells, CoREST is detected ubiquitously in a variety of neural and non-neural cells in adult tissues. In eukaryotic organisms a variety of DNA-protein, as well as protein-protein interactions organize in an elaborated way to elicit proper regulation of differential gene expression critical for developmental processes including neurogenesis. The differential expression pattern of REST and CoREST during development and adulthood suggests REST-independent functions of CoREST. Gene silencing induced by the generation of an inactive chromatin state is becoming increasingly appreciated as an important mechanism of transcriptional regulation.
Издательство: Книга по Требованию
Год:2008
Цена:
2415 руб
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Поиск: The Role of CoREST in Gene Silencing. Initial Identification of Novel Binding Partners for the Developmentally-regulated Co-repressor
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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Экономические отношения между Россией и Казахстаном...

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