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 Systems analysis of the cardiac hypoxia response in Drosophila. Integrating genome-wide data and computational models to explore hypoxia tolerance and metabolism
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Systems analysis of the cardiac hypoxia response in Drosophila. Integrating genome-wide data and computational models to explore hypoxia tolerance and metabolism

автор Jacob F. издательство Книга по Требованию Книги
Cтраниц 256        мягкая обложка       
Аннотация:The dissertation offers clues to hypoxia tolerance in flies, generating hypotheses for further research, and also provides a technology platform for a systematic perturbation analysis. We adopted a systems biology approach to discover important hypoxia-tolerance strategies in ATP-generating metabolism in Drosophila heart. The model was further refined with gene expression data and used with specific metabolomic datasets to study the effects of age on the hypoxia response, and then to study a strain of flies that had been experimentally selected to survive chronic hypoxia. Drosophila is an emerging model for studying genetic influences on heart function, and has also been found to be highly tolerant to hypoxia. This work describes the design of automation technology for rapidly screening the in vivo cardiac hypoxia response in adult flies, the use of NMR metabolomics to gather global metabolic profiles, and the integration of these data into a genome-wide reconstruction of central metabolism.
Автор: Jacob F.
Издательство: Книга по Требованию
Год:2009
Цена:
3233 руб
Нет в наличии
Поиск: Systems analysis of the cardiac hypoxia response in Drosophila. Integrating genome-wide data and computational models to explore hypoxia tolerance and metabolism
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
Ортомолекулярная медицина Orthomol Устрание причин заболеваний. Ортомоль это новый метод для лечения и профилактики болезней. Orthomol - ортомолекулярная медицина.
Генетика и человек

Заслуга Менделя состоит еще и в том, что он дал в руки генетиков мощный метод исследования наследственных признаков – гибридологический анализ, т.е. метод изучения генов путем анализа признаков потомков от определенных скрещиваний. В основе законов Менделя и гибридологического анализа лежат события, происходящие в мейозе: альтернативные аллели находятся в гомологичных хромосомах гибридов и потому расходятся поровну. Именно гибридологический анализ определяет требования к объектам общих генетических исследований: это должны быть легко культивируемые организмы, дающие многочисленное потомство и имеющие короткий репродуктивный период. Таким требованиям среди высших организмов отвечает плодовая мушка дрозофила – Drosophila mela ogas er. На многие годы она стала излюбленным объектом генетических исследований. Усилиями генетиков разных стран на ней были открыты фундаментальные генетические явления. Было установлено, что гены расположены в хромосомах линейно и их распределение у потомков зависит от процессов мейоза; что гены, расположенные в одной и той же хромосоме, наследуются совместно (сцепление генов) и подвержены рекомбинации (кроссинговер).
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