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 Role of Matrix Metalloproteinases in Tissue Remodeling. relevance to pathogenesis of restenosis, aortic aneurism, joint and disc degeneration research
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Role of Matrix Metalloproteinases in Tissue Remodeling. relevance to pathogenesis of restenosis, aortic aneurism, joint and disc degeneration research

автор Leon M.M.D. издательство Книга по Требованию Основы социологии
Cтраниц 88        мягкая обложка       
Аннотация:Matrix metalloproteinases (MMP) are the key enzymes in the pathogenesis of osteoarthritis and inflammatory arthritis. This model has better accessibility and reliable injury assessment techniques in comparison to articular cartilage. We strongly advocate testing of non hydroxamate type matrix metalloproteinase inhibitors in larger animals and in the clinical setting for degenerative joint and disc disease. Dr. Margolin' s "out of the box" thinking, original study design and sharp indepth analysis are a new important step in restenosis, aortic aneurism and metastasis research as well in developing a disease modifying agent for degenerative disc and joint disease. This study was performed on the rat common carotid artery model. This groundbreaking study shows that MMP inhibition resulted in a significant decrease in the cell proliferation and the remodeling of the extracellular matrix up to 2? months after the MMP injection versus untreated control group and that these effects were associated with a marked reduction in MMP-2 activity.
Автор: Leon M.M.D.
Издательство: Книга по Требованию
Год:2009
Цена:
2007 руб
Нет в наличии
Поиск: Role of Matrix Metalloproteinases in Tissue Remodeling. relevance to pathogenesis of restenosis, aortic aneurism, joint and disc degeneration research
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