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 Aspects of Poriferan Apoptosis and Immune System. Aspects of Poriferan
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Aspects of Poriferan Apoptosis and Immune System. Aspects of Poriferan (Suberites domuncula) Apoptosis and Innate Immune System and Evolutionary Implications

автор Berengere L. издательство Книга по Требованию Книги
Cтраниц 176        мягкая обложка       
Аннотация:Its central regulatory function has inspired several approaches that target survivin for cancer therapy. Survivin, a unique member of the family of inhibitors of apoptosis (IAP) proteins, orchestrates intracellular pathways during cell division and apoptosis. To lift the veil on the ancestral function(s) of this key regulatory molecule, a survivin homologue of the phylogenetically oldest extant metazoan taxon (phylum Porifera) was identified and functionally characterized. Analyses in early-branching Metazoa so far propose an exclusive role of survivin as a chromosomal passenger protein, whereas only later during evolution the second, complementary antiapoptotic function might have arisen, concurrent with increased organismal complexity. Additionally, new components of the innate defense sentinel in sponges were also identified. This new prototypes could represent a very efficient defense mechanism and may correspond to a new family of intracellular sensing protein, forming a subclass of pattern recognition receptors (PRR).
Автор: Berengere L.
Издательство: Книга по Требованию
Год:2009
Цена:
2783 руб
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Поиск: Aspects of Poriferan Apoptosis and Immune System. Aspects of Poriferan (Suberites domuncula) Apoptosis and Innate Immune System and Evolutionary Implications
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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