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 How type 1 diabetes affects the brain Type 1 Diabetes, Glucocorticoids and the Brain
Наименование:

How type 1 diabetes affects the brain Type 1 Diabetes, Glucocorticoids and the Brain: a sweet connection.

автор Yanina R. издательство Книга по Требованию Органическая химия
Cтраниц 136        мягкая обложка       
Аннотация:Furthermore, diabetic animals present hippocampal pathology suggesting mild neurodegeneration. Concurrently, cognitive impairments related to spatial memory were found. Finally, normalization of the hippocampal dysfunction and the impaired cognition of diabetic mice were achieved using a glucocorticoid receptor (GR) antagonist. Moreover, the GRs are crucial for the mechanism that underlies the disruption of hippocampal integrity and the impairment of cognitive performance. Here it is demonstrated that hyperresponsiveness of the adrenal glands is the primary event leading to hypercorticism in diabetic mice. The general hypothesis tested that the onset of diabetes induces first dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis and subsequently hypersecretion of glucocorticoids which then renders the brain more vulnerable to metabolic insults causing damage and concomitant cognitive disturbances. However the reason why T1D affects CNS integrity remains to be elucidated. These data indicate that glucocorticoids play a causal role in diabetes neuropathology. Type 1 diabetes (T1D) can impact the integrity of the central nervous system (CNS).
Автор: Yanina R.
Издательство: Книга по Требованию
Год:2009
Цена:
2415 руб
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Поиск: How type 1 diabetes affects the brain Type 1 Diabetes, Glucocorticoids and the Brain: a sweet connection.



Корея

По условиям заключаемых контрактов подобного рода поставки финансировались кредитами из расчета 3% годовых с по­гашением задолженности в трехлетний срок. Помимо указанного Южная Корея была вынуждена приобретать и машинное оборудование, непосредственно используемоев произ­водственных процессах. Как правило, закупки станков и агрега­тов сопровождались приобретением прав на использование техно­логических процессов. Потребность в них увеличивалась с каждым годом. Соответственно росли и отчисления на оплату как самой техники, так и технологии "k ow how". Всего за 1962-1982гг. между Южной Кореей и развитыми капиталистическими странами бы­ла зафиксирована 2281 сделка на приобретение технических " ow how" на общую сумму 681 млн.$, что составило 47,7% суммы пря­мых инвестиций за тот же период. Из приведенных в табл.1 данных видно, что львиная до­лясделок, связанных с приобретением производственного оборудо­вания и связанных с ним "k ow how", заключалось с японскими бизнесменами(56,4%), хотя  к  сотрудничеству  с южнокорейскими фирмами на этом поприще они приступили на  4  года  позже  чем американские и прочие деловые круги.
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