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 Oral Tolerance in Transplantation. Oral administration of alloantigen prolongs kidney allograft survival by generating intragraft T regulatory cells
Наименование:

Oral Tolerance in Transplantation. Oral administration of alloantigen prolongs kidney allograft survival by generating intragraft T regulatory cells

автор Juan Z. издательство Книга по Требованию Медико-биологические дисциплины
Cтраниц 160        мягкая обложка       
Аннотация:Oral administration of antigen prior to systemic challenge has been demonstrated to suppress systemic immune responses, and this antigen specific suppression is termed oral tolerance. The book described that oral exposure to alloantigen prolongs kidney allograft survival in rats in an allospecific manner. The prolongation is due to a generation of CD8+ T regulatory (Treg) cells in the recipient. These Treg cells may shift immune responses towards type 2 responses and delete alloreactive T lymphocytes through Fas/FasL interaction. A major goal of transplantation research is to develop a specific immune unresponsiveness to alloantigen. This book assesses whether oral tolerance can be used to prolong kidney allograft survival and investigates the mechanisms by which this survival is prolonged. The CD8+ Treg cells are present in the spleen, mesenteric lymph nodes and kidney allograft and able to transfer the graft prolongation to naive recipient.
Автор: Juan Z.
Издательство: Книга по Требованию
Год:2010
Цена:
2415 руб
Нет в наличии
Поиск: Oral Tolerance in Transplantation. Oral administration of alloantigen prolongs kidney allograft survival by generating intragraft T regulatory cells
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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